{"id":"W4367296748","doi":"10.1016/j.eururo.2023.03.030","title":"Avelumab First-line Maintenance Therapy for Advanced Urothelial Carcinoma: Comprehensive Clinical Subgroup Analyses from the JAVELIN Bladder 100 Phase 3 Trial","year":2023,"lang":"en","type":"article","venue":"European Urology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Javelin; Avelumab; Urothelial carcinoma; Metastatic Urothelial Carcinoma; Oncology; Internal medicine; Carcinoma; Chemotherapy; Clinical trial; Bladder cancer; Urology; Immunotherapy; Pembrolizumab; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007662715,0.001232853,0.002482815,0.0005901592,0.0003662411,0.001005874,0.0007906996,0.0006151997,0.002479242],"category_scores_gemma":[0.004746817,0.0003615823,0.007186228,0.000889195,0.0003421197,0.0005802355,0.0006531193,0.001244702,0.0002553792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006725765,"about_ca_system_score_gemma":0.001447442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009374919,"about_ca_topic_score_gemma":0.00499375,"domain_scores_codex":[0.997049,0.00206417,0.00026317,0.0002743076,0.0001906517,0.0001587413],"domain_scores_gemma":[0.9975659,0.0009558769,0.000611725,0.0004493207,0.0001163537,0.0003008916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.7395663,0.001702434,0.05681917,0.004134693,0.1004662,0.0003230985,0.0002520694,0.004819494,0.007583976,0.000454625,0.008038169,0.07583991],"study_design_scores_gemma":[0.4849298,0.04764751,0.268106,0.0008219304,0.1695481,0.001005135,0.0003525778,0.006496011,0.003290127,0.003629068,0.01392519,0.0002486715],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9436316,0.03936984,0.002424872,0.0009464953,0.0001802603,0.002490235,0.008640104,0.0001367845,0.002179785],"genre_scores_gemma":[0.9803175,0.00434101,0.002060402,0.0006738949,0.0001777978,0.002337814,0.009283339,0.0000444403,0.0007637913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007662715,"threshold_uncertainty_score":0.04052478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1709709398084595,"score_gpt":0.4281932307307954,"score_spread":0.2572222909223359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}