{"id":"W4367298708","doi":"10.1002/pro.4648","title":"A metal‐dependent conformational change provides a structural basis for the inhibition of CTP synthase by gemcitabine‐5′‐triphosphate","year":2023,"lang":"en","type":"article","venue":"Protein Science","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of Waterloo","funders":"Division of Materials Research; National Institute of General Medical Sciences; National Institutes of Health; Research Nova Scotia; IWK Health Centre; Mitacs; Empire State Development Corporation; Nova Scotia Health Research Foundation; University of Saskatchewan; Natural Sciences and Engineering Research Council of Canada; Canadian Light Source; Dartmouth College; QEII Foundation; Dalhousie Medical Research Foundation; Terry Fox Research Institute; Beatrice Hunter Cancer Research Institute; Dalhousie University; Health Sciences Centre Foundation; Cancer Research Institute; Canadian Institutes of Health Research; National Science Foundation","keywords":"ATP synthase; Chemistry; Conformational change; Biochemistry; Biophysics; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007508421,0.0002802724,0.0002132392,0.00005663479,0.0002207166,0.0003313532,0.0003791432,0.0003384902,0.001501324],"category_scores_gemma":[0.0001359016,0.0001842474,0.0002334566,0.0000775302,0.0002830685,0.0002152839,0.0001799762,0.0005114821,0.0003124674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004760204,"about_ca_system_score_gemma":0.0002465392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007502117,"about_ca_topic_score_gemma":0.0008153399,"domain_scores_codex":[0.9999415,0.000007310834,0.000004838737,0.00001711442,0.00001554825,0.00001373118],"domain_scores_gemma":[0.9999509,0.000007786224,0.00001262346,0.000006396697,0.000005744641,0.00001661031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002928308,0.00007496579,0.0005325347,0.0000498374,0.00001544663,0.0003524898,0.00003117793,0.002051474,0.9939163,0.001243173,0.0001336229,0.001306335],"study_design_scores_gemma":[0.0002163948,0.0004489841,0.006758359,0.00001528644,0.00002984222,0.0006950342,0.00007691636,0.02100833,0.965867,0.000805589,0.004047607,0.00003074943],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930841,0.0003838664,0.003773967,0.0001964126,0.00003908623,0.00002572136,0.0001218347,0.0001121002,0.002262955],"genre_scores_gemma":[0.9981954,0.0001143853,0.0009022652,0.00004527285,0.000004221981,0.00001133793,0.0001516554,0.000008437365,0.0005671085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001501324,"threshold_uncertainty_score":0.005022407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0297836155902365,"score_gpt":0.3029559947869826,"score_spread":0.2731723791967461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}