{"id":"W4367298708","doi":"10.1002/pro.4648","title":"A metal‐dependent conformational change provides a structural basis for the inhibition of CTP synthase by gemcitabine‐5′‐triphosphate","year":2023,"lang":"en","type":"article","venue":"Protein Science","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of Waterloo","funders":"Division of Materials Research; National Institute of General Medical Sciences; National Institutes of Health; Research Nova Scotia; IWK Health Centre; Mitacs; Empire State Development Corporation; Nova Scotia Health Research Foundation; University of Saskatchewan; Natural Sciences and Engineering Research Council of Canada; Canadian Light Source; Dartmouth College; QEII Foundation; Dalhousie Medical Research Foundation; Terry Fox Research Institute; Beatrice Hunter Cancer Research Institute; Dalhousie University; Health Sciences Centre Foundation; Cancer Research Institute; Canadian Institutes of Health Research; National Science Foundation","keywords":"ATP synthase; Chemistry; Conformational change; Biochemistry; Biophysics; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000698993,0.00008792209,0.00007799788,0.00005076302,0.0001937883,0.00004279313,0.0003035583,0.00005017531,0.00001397591],"category_scores_gemma":[0.00052598,0.00005859517,0.00006358093,0.0003624665,0.0004505792,0.0000200576,0.0002169111,0.00005475014,0.000005020725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001373639,"about_ca_system_score_gemma":0.0001167237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004573232,"about_ca_topic_score_gemma":0.000004044508,"domain_scores_codex":[0.9988692,0.00001864568,0.0001579582,0.0002566401,0.0004150778,0.0002824743],"domain_scores_gemma":[0.9994094,0.00002099932,0.000073674,0.0002063609,0.0002213321,0.00006827737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005644294,0.00001037297,0.00001944005,0.00005163617,0.000008755228,3.175897e-7,0.0000408125,0.000002549124,0.9942083,0.0003285786,0.0001849545,0.005087861],"study_design_scores_gemma":[0.0002536133,0.0001293218,0.0001926176,0.00001490895,0.000006147006,0.000002532442,0.0000563373,0.001356047,0.9960997,0.0002235242,0.001582715,0.00008260824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949431,0.0007121044,0.001535973,0.0011538,0.00004445226,0.001368443,0.0001787559,0.00001255759,0.00005080312],"genre_scores_gemma":[0.9983985,0.000029005,0.0003422097,0.0001202209,0.00004494898,0.0007464635,0.0000805356,0.000006581105,0.0002314696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005005253,"threshold_uncertainty_score":0.2389442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0297836155902365,"score_gpt":0.3029559947869826,"score_spread":0.2731723791967461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}