{"id":"W4367302418","doi":"10.1212/wnl.0000000000203929","title":"A Phase 2, Randomized, Placebo-Controlled Trial to Evaluate the Effects of SAGE-718 in Patients with Alzheimer’s Disease: Study Design (P8-6.010)","year":2023,"lang":"en","type":"article","venue":"Neurology","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Dementia; Placebo; Clinical Dementia Rating; Randomized controlled trial; Medicine; Alzheimer's disease; Montreal Cognitive Assessment; Wechsler Adult Intelligence Scale; Internal medicine; Cognition; Disease; Psychiatry; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002635262,0.002096226,0.002820371,0.000508798,0.0006873849,0.0008512967,0.00115532,0.003168922,0.01231596],"category_scores_gemma":[0.001725189,0.0008222476,0.001859795,0.0004482118,0.00108405,0.001188819,0.00046105,0.002929532,0.001677436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006155748,"about_ca_system_score_gemma":0.002467582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007011784,"about_ca_topic_score_gemma":0.002274111,"domain_scores_codex":[0.9991164,0.000467516,0.00005489542,0.0001496633,0.00007810238,0.0001334041],"domain_scores_gemma":[0.9990098,0.0002332116,0.0002074777,0.00006378399,0.00008744693,0.0003983091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9697011,0.01132889,0.0003233005,0.0008011206,0.0005272416,0.0000505447,0.00003789903,0.0001646653,0.002803072,0.0001299702,0.001539119,0.01259303],"study_design_scores_gemma":[0.9690681,0.02969594,0.0004040395,0.00001344801,0.00009548595,0.00001371723,0.000005182366,0.0001060751,0.0001503016,0.00005565759,0.0003856254,0.000006470592],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.8954661,0.007916434,0.002867756,0.002707818,0.002606705,0.07579032,0.004744932,0.0005435609,0.007356417],"genre_scores_gemma":[0.866383,0.004649651,0.01101376,0.007338479,0.001908868,0.0965819,0.002790645,0.00006112565,0.009272523],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.01231596,"threshold_uncertainty_score":0.041201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03023733176551368,"score_gpt":0.3338666425104346,"score_spread":0.3036293107449209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}