{"id":"W4367303575","doi":"10.1212/wnl.0000000000203868","title":"GRADUATE I AND II: Findings of Two Phase III Randomized Placebo-controlled Studies Assessing the Efficacy and Safety of Subcutaneous Gantenerumab in Early Alzheimer’s Disease (AD) (S26.010)","year":2023,"lang":"en","type":"article","venue":"Neurology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Placebo; Dementia; Medicine; Internal medicine; Randomized controlled trial; Clinical endpoint; Clinical Dementia Rating; Alzheimer's disease; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007220575,0.002210011,0.002738188,0.0004883231,0.0007096109,0.001526857,0.001334971,0.003643374,0.008399933],"category_scores_gemma":[0.0061577,0.000968936,0.003707709,0.0004242205,0.001711971,0.001464176,0.0007812202,0.004327017,0.001233614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001064624,"about_ca_system_score_gemma":0.002359157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008751841,"about_ca_topic_score_gemma":0.002892693,"domain_scores_codex":[0.9973413,0.001401495,0.0002768475,0.0004409194,0.0002645317,0.0002748662],"domain_scores_gemma":[0.9948462,0.001282848,0.001409519,0.0005023414,0.0004992699,0.001459776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9409488,0.014207,0.001650183,0.002182274,0.002747502,0.00006205965,0.0001618857,0.0001627861,0.00868187,0.0002053119,0.003582071,0.02540824],"study_design_scores_gemma":[0.8961163,0.09506712,0.004034181,0.000106498,0.001153625,0.00004758297,0.00003273843,0.00007889394,0.00104613,0.0001325506,0.002157268,0.00002713131],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9022785,0.01464884,0.003506853,0.004792456,0.002025579,0.05351384,0.01139268,0.0004399285,0.007401339],"genre_scores_gemma":[0.9119453,0.007028479,0.009984678,0.009028176,0.00269713,0.04494179,0.007124493,0.0001085749,0.007141476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008399933,"threshold_uncertainty_score":0.03818655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05792710409980973,"score_gpt":0.3805747136228375,"score_spread":0.3226476095230277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}