{"id":"W4367304609","doi":"10.1212/wnl.0000000000202202","title":"Low Disease Activity Over 4 Years of Ocrelizumab Therapy in Treatment-Naive Patients With Early-Stage Relapsing-Remitting Multiple Sclerosis; the Phase IIIb ENSEMBLE Study (S46.004)","year":2023,"lang":"en","type":"article","venue":"Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Medicine; Multiple sclerosis; Expanded Disability Status Scale; Ocrelizumab; Stage (stratigraphy); Internal medicine; Magnetic resonance imaging; Relapsing remitting; Radiology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002653295,0.0009550406,0.0014419,0.0001894125,0.0004463979,0.0007146332,0.0005153381,0.0009626339,0.001636732],"category_scores_gemma":[0.0009815253,0.0003342636,0.001154546,0.0002732971,0.0004387933,0.0005772923,0.0003719508,0.001886545,0.0003809181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004499839,"about_ca_system_score_gemma":0.0009852622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001214268,"about_ca_topic_score_gemma":0.002898889,"domain_scores_codex":[0.9995291,0.0002327399,0.00002836469,0.00007289273,0.00004986302,0.00008707443],"domain_scores_gemma":[0.9992222,0.00009135771,0.000195823,0.00008203745,0.00006537171,0.0003432522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7944445,0.03048929,0.07950202,0.0005777201,0.003698299,0.0001776047,0.0002438923,0.001690488,0.0207953,0.0001113864,0.004924761,0.0633447],"study_design_scores_gemma":[0.4308763,0.324291,0.2336861,0.00009410771,0.002174881,0.0004205345,0.00009226269,0.001983686,0.002998464,0.0002884924,0.003011506,0.00008269002],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996188,0.001050666,0.0001859523,0.0001402694,0.00005285247,0.0005096145,0.001050097,0.00002685779,0.0007957282],"genre_scores_gemma":[0.9947491,0.0004430369,0.0006691096,0.0007102621,0.000136927,0.0005544656,0.002095678,0.00001120486,0.0006301933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002653295,"threshold_uncertainty_score":0.01403219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06316467877423104,"score_gpt":0.3241196361038866,"score_spread":0.2609549573296555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}