{"id":"W4367304614","doi":"10.1212/wnl.0000000000203305","title":"RACK1 Knockdown is a Potential Therapeutic Target in ALS and FTLD-TDP (P1-6.003)","year":2023,"lang":"nl","type":"article","venue":"Neurology","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Amorfix (Canada)","funders":"","keywords":"Gene knockdown; Drosophila melanogaster; HEK 293 cells; Transfection; Cell biology; RNA interference; Compound eye; Molecular biology; Biology; Chemistry; Cell culture; RNA; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00028916,0.0004646099,0.0005306448,0.0002967794,0.0005158569,0.0004745556,0.0003906632,0.0008163273,0.005476833],"category_scores_gemma":[0.0001838096,0.0001811315,0.0003801245,0.0003010391,0.0003852335,0.0005210728,0.000195833,0.001460377,0.001180781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005975452,"about_ca_system_score_gemma":0.0004618719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002226353,"about_ca_topic_score_gemma":0.003030336,"domain_scores_codex":[0.9998093,0.00002698984,0.00002070445,0.00004616204,0.00004642109,0.0000503901],"domain_scores_gemma":[0.9999008,0.00001761015,0.00002611358,0.00001208794,0.00001184487,0.00003161299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001559891,0.0006747682,0.0003545349,0.0001763683,0.00003503391,0.0001756309,0.00004985087,0.0004601012,0.9881192,0.0007850601,0.001166612,0.006442939],"study_design_scores_gemma":[0.0004116748,0.005512457,0.005245328,0.00002856132,0.0001029236,0.0007028389,0.00008559302,0.002035012,0.9749829,0.0003694272,0.01050007,0.00002321151],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812948,0.002636876,0.003997688,0.001065396,0.0002216119,0.0002616276,0.003108876,0.0004217673,0.006991433],"genre_scores_gemma":[0.9867824,0.001001392,0.003405636,0.0001897608,0.00001664257,0.0003137304,0.001314298,0.00008468631,0.006891483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005476833,"threshold_uncertainty_score":0.01832181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007751278989666804,"score_gpt":0.238456312099279,"score_spread":0.2307050331096122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}