{"id":"W4367305551","doi":"10.1212/wnl.0000000000202933","title":"Remibrutinib: A Novel BTKi in Development for MS With a Favorable Safety Profile in Various Autoimmune Disorders (P7-3.015)","year":2023,"lang":"en","type":"article","venue":"Neurology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Safety profile; Medicine; Internal medicine; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007508923,0.0005735158,0.0004848833,0.0003536427,0.0003396436,0.0006264661,0.0004142553,0.0004924747,0.004776777],"category_scores_gemma":[0.0002587457,0.0001441286,0.0005327488,0.0003248466,0.0002046967,0.0004064541,0.000351483,0.001047359,0.001481806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000599497,"about_ca_system_score_gemma":0.001095674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007391702,"about_ca_topic_score_gemma":0.002696338,"domain_scores_codex":[0.9997997,0.00004145925,0.00001669577,0.00003022637,0.00005312721,0.00005883956],"domain_scores_gemma":[0.9998339,0.00001385475,0.00003878242,0.00001372572,0.00002154028,0.00007812308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.02114871,0.003741646,0.01230656,0.001414426,0.0003870972,0.001579953,0.0002251824,0.001657759,0.3386982,0.001593837,0.02163691,0.5956097],"study_design_scores_gemma":[0.07543691,0.1363325,0.1237214,0.0005326056,0.001551194,0.02698744,0.0001821079,0.007356616,0.3213561,0.001716195,0.304652,0.0001749252],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9079636,0.03919837,0.008293844,0.00334394,0.0004402803,0.002820689,0.006962308,0.001023555,0.02995346],"genre_scores_gemma":[0.9578222,0.0106243,0.01141552,0.001952054,0.0003282684,0.0009299249,0.007749334,0.0000962726,0.009082143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004776777,"threshold_uncertainty_score":0.01597989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02098715940100143,"score_gpt":0.2868516981313222,"score_spread":0.2658645387303207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}