{"id":"W4367316613","doi":"10.1016/j.molmet.2023.101731","title":"Semaphorin 4B is an ADAM17-cleaved adipokine that inhibits adipocyte differentiation and thermogenesis","year":2023,"lang":"en","type":"article","venue":"Molecular Metabolism","topic":"Adipokines, Inflammation, and Metabolic Diseases","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Social Fund; Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición; Instituto de Salud Carlos III; Fundação para a Ciência e a Tecnologia; Medical Research Council; Marie Curie; Queen's University; Generalitat de Catalunya; Ministerio de Ciencia, Innovación y Universidades; Queen's University Belfast; European Regional Development Fund; Deutsche Forschungsgemeinschaft","keywords":"Thermogenesis; Biology; Adipocyte; Adipose tissue; Adipogenesis; Endocrinology; Adipokine; Autocrine signalling; Internal medicine; Cell biology; Glucose homeostasis; Brown adipose tissue; Energy homeostasis; Insulin resistance; Insulin; Receptor; Medicine; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002833556,0.0003843426,0.0005864548,0.0004383598,0.0001633592,0.00006998997,0.0001454813,0.0001419425,0.0003233801],"category_scores_gemma":[0.0001177474,0.0003388358,0.0002062195,0.0006206622,0.0000930019,0.0002693417,0.00009232706,0.00014174,0.0001149716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000204523,"about_ca_system_score_gemma":0.0000925826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009981666,"about_ca_topic_score_gemma":0.00001349009,"domain_scores_codex":[0.9977131,0.0001550441,0.0003968503,0.0006127626,0.0006377646,0.0004845018],"domain_scores_gemma":[0.9984861,0.0000295593,0.0001603504,0.0006668146,0.0001827234,0.000474446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004267959,0.000380723,0.01585454,0.0004432019,0.0009835399,0.000240606,0.003212588,0.00003868493,0.8759489,0.004838073,0.001919566,0.09571278],"study_design_scores_gemma":[0.002146728,0.00004542362,0.6351516,0.00005604348,0.001265387,0.00003369167,0.0001238943,0.0007695542,0.3349356,0.0005898284,0.0245216,0.0003607144],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895225,0.007242624,0.0005367916,0.0006460401,0.0003340322,0.0006133725,0.00008296254,0.0003707206,0.0006509831],"genre_scores_gemma":[0.9942321,0.001578773,0.0003070083,0.001328755,0.0004229191,0.00009548222,0.0003646516,0.00009993769,0.001570391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.619297,"threshold_uncertainty_score":0.9999064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02211076700125674,"score_gpt":0.2594724523371348,"score_spread":0.2373616853358781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}