{"id":"W4367316613","doi":"10.1016/j.molmet.2023.101731","title":"Semaphorin 4B is an ADAM17-cleaved adipokine that inhibits adipocyte differentiation and thermogenesis","year":2023,"lang":"en","type":"article","venue":"Molecular Metabolism","topic":"Adipokines, Inflammation, and Metabolic Diseases","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Social Fund; Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición; Instituto de Salud Carlos III; Fundação para a Ciência e a Tecnologia; Medical Research Council; Marie Curie; Queen's University; Generalitat de Catalunya; Ministerio de Ciencia, Innovación y Universidades; Queen's University Belfast; European Regional Development Fund; Deutsche Forschungsgemeinschaft","keywords":"Thermogenesis; Biology; Adipocyte; Adipose tissue; Adipogenesis; Endocrinology; Adipokine; Autocrine signalling; Internal medicine; Cell biology; Glucose homeostasis; Brown adipose tissue; Energy homeostasis; Insulin resistance; Insulin; Receptor; Medicine; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002285934,0.0005124818,0.0003770611,0.000337013,0.0001745317,0.0002328517,0.0002195182,0.0002849409,0.001568271],"category_scores_gemma":[0.0001443152,0.0001595709,0.0004256043,0.0001880463,0.0003200193,0.0001792297,0.0002226245,0.0006269165,0.0005077292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000276537,"about_ca_system_score_gemma":0.0002923958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003546517,"about_ca_topic_score_gemma":0.0005542102,"domain_scores_codex":[0.9998212,0.00003255299,0.00002189707,0.00002566607,0.00006751052,0.00003111761],"domain_scores_gemma":[0.9998708,0.00001606684,0.00004533337,0.00001342555,0.00001858376,0.00003583245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001591864,0.00002696537,0.0003162902,0.00005683423,0.00001458618,0.00008673586,0.000005752905,0.000091355,0.9975044,0.00006229876,0.00006699385,0.001608485],"study_design_scores_gemma":[0.00004673792,0.0005012444,0.003974317,0.000009003158,0.00003703421,0.0006254326,0.00001700586,0.0007005873,0.9896854,0.00004724319,0.004351499,0.000004567411],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801472,0.007521017,0.008486516,0.0003949448,0.0001526589,0.00006878946,0.00085876,0.0002646591,0.002105247],"genre_scores_gemma":[0.9801183,0.003782341,0.008973032,0.0001685841,0.00004598551,0.000111188,0.001219582,0.00005430031,0.005526696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001568271,"threshold_uncertainty_score":0.005246341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02211076700125674,"score_gpt":0.2594724523371348,"score_spread":0.2373616853358781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}