{"id":"W4367316925","doi":"10.3390/ijms24097983","title":"The Role of the Estrogen-Related Receptor Alpha (ERRa) in Hypoxia and Its Implications for Cancer Metabolism","year":2023,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Instituto Mexicano del Seguro Social; Consejo Nacional de Ciencia y Tecnología","keywords":"Estrogen-related receptor alpha; Estrogen receptor alpha; Hypoxia (environmental); HIF1A; Estrogen receptor; Estrogen; Alpha (finance); Metabolism; Endocrinology; Internal medicine; Cancer; Cancer research; Biology; Chemistry; Bioinformatics; Breast cancer; Medicine; Clinical psychology; Oxygen; Angiogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003350466,0.0006438086,0.0008839942,0.001789973,0.0002679254,0.0006821563,0.0005737763,0.0008384475,0.002944761],"category_scores_gemma":[0.0004558179,0.0002253989,0.0003483179,0.001840981,0.000362034,0.001023607,0.000540935,0.001361978,0.001718628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005150327,"about_ca_system_score_gemma":0.0009584589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001006776,"about_ca_topic_score_gemma":0.001756017,"domain_scores_codex":[0.9998966,0.00001798342,0.00001559209,0.00001778444,0.00004009066,0.00001192441],"domain_scores_gemma":[0.9998362,0.00007430753,0.00002147388,0.000004766508,0.00004369647,0.00001949419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008297135,0.00005205656,0.0001900525,0.01317255,0.00007346685,0.000326267,0.00007196292,0.0004023619,0.002103623,0.004511155,0.03795715,0.9410563],"study_design_scores_gemma":[0.00001357943,0.00008519723,0.0008837571,0.002346517,0.00006890874,0.001716737,0.00005893885,0.00005838295,0.0003327054,0.001816634,0.9926059,0.00001273005],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008851627,0.9985332,0.00007209105,0.0002402434,0.0002161421,0.000002103122,0.00001110956,0.000004873114,0.0008316551],"genre_scores_gemma":[0.0003908877,0.9987924,0.00008891222,0.0001350433,0.000143499,0.000002914349,0.00001627631,8.173724e-7,0.0004292214],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002944761,"threshold_uncertainty_score":0.009851217,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03158137515028231,"score_gpt":0.3538501486856073,"score_spread":0.322268773535325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}