{"id":"W4367320450","doi":"10.1172/jci161453","title":"Pressure overload induces ISG15 to facilitate adverse ventricular remodeling and promote heart failure","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University; Ted Rogers Centre for Heart Research; University Health Network; University of Toronto; Toronto General Hospital; St. Michael's Hospital","funders":"Biotechnology and Biological Sciences Research Council; Heart and Stroke Foundation of Canada; Banting and Best Diabetes Centre, University of Toronto; Canadian Institutes of Health Research; University of Toronto; Diabetes Canada","keywords":"Downregulation and upregulation; Ventricular remodeling; ISG15; Pressure overload; Heart failure; Inflammation; Internal medicine; Endocrinology; Cardiomyopathy; Cell biology; Filamin; Myocyte; Diabetic cardiomyopathy; Ubiquitin; Biology; Chemistry; Medicine; Cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00154608,0.0001064956,0.0002242424,0.00006531049,0.00005198858,0.00002282487,0.0001309011,0.000177177,0.000004916375],"category_scores_gemma":[0.003268367,0.00009357845,0.0001491766,0.0001790605,0.00007899376,0.0000165461,0.00008374576,0.0002157883,0.00001437046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005506078,"about_ca_system_score_gemma":0.0001589283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003590663,"about_ca_topic_score_gemma":0.000001563872,"domain_scores_codex":[0.9984591,0.0001903794,0.0007122306,0.0002251821,0.0002650952,0.0001480021],"domain_scores_gemma":[0.9988782,0.0000690631,0.0002972319,0.0001749708,0.0002454957,0.0003349753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003451321,0.00008843791,0.04759677,0.0001118302,0.0002090074,0.00005427186,0.000335351,0.01559107,0.8901578,0.00002429444,0.04171979,0.003766285],"study_design_scores_gemma":[0.005030524,0.003680077,0.1404241,0.0009935658,0.0005492503,0.0001897472,0.0005924633,0.007591317,0.5123439,0.006940091,0.3206509,0.001014017],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996712,0.0003150158,0.0002420106,0.002274131,0.000271991,0.0001489563,0.00001468237,0.00001234083,0.000008841519],"genre_scores_gemma":[0.994607,0.00003960406,0.004004342,0.0006744224,0.0005114703,0.000003165033,0.0000202936,0.00001291278,0.0001268441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3778138,"threshold_uncertainty_score":0.3912777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09130328682495234,"score_gpt":0.3491667649176099,"score_spread":0.2578634780926575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}