{"id":"W4367320450","doi":"10.1172/jci161453","title":"Pressure overload induces ISG15 to facilitate adverse ventricular remodeling and promote heart failure","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University; Ted Rogers Centre for Heart Research; University Health Network; University of Toronto; Toronto General Hospital; St. Michael's Hospital","funders":"Biotechnology and Biological Sciences Research Council; Heart and Stroke Foundation of Canada; Banting and Best Diabetes Centre, University of Toronto; Canadian Institutes of Health Research; University of Toronto; Diabetes Canada","keywords":"Downregulation and upregulation; Ventricular remodeling; ISG15; Pressure overload; Heart failure; Inflammation; Internal medicine; Endocrinology; Cardiomyopathy; Cell biology; Filamin; Myocyte; Diabetic cardiomyopathy; Ubiquitin; Biology; Chemistry; Medicine; Cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001669605,0.0003068472,0.0001910573,0.0001922158,0.0001398105,0.0002671765,0.0001254699,0.0002760444,0.001299907],"category_scores_gemma":[0.00007892536,0.00009947795,0.0002732885,0.00009248497,0.0002818553,0.0001503172,0.0002502502,0.0004172189,0.0002007577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002112101,"about_ca_system_score_gemma":0.0001599886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001866136,"about_ca_topic_score_gemma":0.0004137844,"domain_scores_codex":[0.9998916,0.00001927531,0.000008407344,0.00002527475,0.00002419493,0.00003117814],"domain_scores_gemma":[0.99992,0.0000057935,0.0000316568,0.000007767279,0.000006497651,0.00002815993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002083719,0.00002578204,0.00167992,0.00003044706,0.00001250055,0.0001310467,0.00001254108,0.00003073632,0.9963235,0.0001107311,0.00005737128,0.001377107],"study_design_scores_gemma":[0.0001093369,0.001240625,0.1583901,0.0000551326,0.00009106209,0.0016081,0.0001474564,0.001387828,0.8297629,0.0005949541,0.006598308,0.00001422161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950363,0.001788537,0.001625131,0.0001959977,0.00005138152,0.00002052183,0.0001723701,0.00004885673,0.001060892],"genre_scores_gemma":[0.9972368,0.0005989551,0.0008076692,0.0001570721,0.00001758371,0.00001671817,0.0001939709,0.000009808275,0.0009612206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001299907,"threshold_uncertainty_score":0.004348636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09130328682495234,"score_gpt":0.3491667649176099,"score_spread":0.2578634780926575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}