{"id":"W4367320619","doi":"10.3390/molecules28083481","title":"Synthesis and Evaluation of 68Ga-Labeled (2S,4S)-4-Fluoropyrrolidine-2-Carbonitrile and (4R)-Thiazolidine-4-Carbonitrile Derivatives as Novel Fibroblast Activation Protein-Targeted PET Tracers for Cancer Imaging","year":2023,"lang":"en","type":"article","venue":"Molecules","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Terry Fox Research Institute","funders":"Canadian Institutes of Health Research; University of British Columbia","keywords":"Fibroblast activation protein, alpha; Biodistribution; Pharmacophore; Cancer research; Chemistry; In vivo; Fibroblast; Cancer; In vitro; Molecular biology; IC50; Cancer cell; Medicine; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005466176,0.0002470744,0.0004375312,0.0004574561,0.0001520986,0.00004154095,0.00005297061,0.00005873236,0.0001208161],"category_scores_gemma":[0.001086964,0.0002312122,0.0001129699,0.0006324759,0.000134822,0.0001695895,0.00004217592,0.0001184312,0.00000266541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009536066,"about_ca_system_score_gemma":0.0002086134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001751068,"about_ca_topic_score_gemma":0.00001816947,"domain_scores_codex":[0.9982741,0.00009726975,0.0003886765,0.0004299945,0.0005209844,0.0002889251],"domain_scores_gemma":[0.9986929,0.0002244223,0.0002482898,0.0001923052,0.000512795,0.0001293019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002510116,0.00008444856,0.0005506627,0.0003116594,0.0001721744,0.000004816546,0.0003220407,0.0001345783,0.9944539,0.000119107,0.000119402,0.003476163],"study_design_scores_gemma":[0.002588011,0.0001009484,0.006214231,0.001656389,0.0003626245,0.00001602968,0.0009876754,0.102342,0.8850945,0.0003326944,0.0000681064,0.0002368248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958125,0.0001864943,0.0004674769,0.002044827,0.00001028489,0.0009292996,0.0001173752,0.0001100301,0.0003217477],"genre_scores_gemma":[0.9973165,0.0000383891,0.001414234,0.0001354935,0.00007359816,0.0006689543,0.0001337367,0.00004680853,0.0001723113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1093595,"threshold_uncertainty_score":0.942856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02907015579726454,"score_gpt":0.3143445042058817,"score_spread":0.2852743484086172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}