{"id":"W4367322453","doi":"10.1016/j.stemcr.2023.04.001","title":"Generation, genomic characterization, and differentiation of triploid human embryonic stem cells","year":2023,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Azrieli Foundation; Rosetrees Trust","keywords":"Biology; Ploidy; Embryonic stem cell; Transcriptome; Genetics; Stem cell; Cell biology; Embryo; Cellular differentiation; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003435637,0.0002101811,0.0002130148,0.0006322387,0.0002917754,0.0002986014,0.0002617305,0.0002280044,0.002151737],"category_scores_gemma":[0.000405247,0.0001747713,0.0002083464,0.0004079186,0.0002305204,0.000177707,0.0003501995,0.0004035186,0.001327957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001586545,"about_ca_system_score_gemma":0.0002517216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005855913,"about_ca_topic_score_gemma":0.0008912194,"domain_scores_codex":[0.9998168,0.00002275218,0.00003542108,0.00004200376,0.00006786545,0.0000152345],"domain_scores_gemma":[0.9998407,0.0000254612,0.0000230044,0.00004965038,0.00003816183,0.00002303749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006595901,0.00002284503,0.0007071967,0.00008074903,0.000007225388,0.0002108696,0.0001148429,0.000289584,0.9874134,0.0006717151,0.0002598197,0.01015589],"study_design_scores_gemma":[0.00003765872,0.0004593403,0.01673721,0.00003813265,0.00006362474,0.002009254,0.0001901396,0.002107472,0.9288591,0.0007619882,0.04870469,0.0000313032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7791012,0.004993749,0.1730893,0.0004881108,0.0001375991,0.002700898,0.02579538,0.000585748,0.01310796],"genre_scores_gemma":[0.7919078,0.006538471,0.1363335,0.0003582891,0.00004118649,0.00159516,0.05047849,0.000326402,0.01242078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002151737,"threshold_uncertainty_score":0.007198274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02083870885527654,"score_gpt":0.250141992183733,"score_spread":0.2293032833284564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}