{"id":"W4367368423","doi":"10.1089/hum.2023.059","title":"Advances in CRISPR/Cas9 Genome Editing for the Treatment of Muscular Dystrophies","year":2023,"lang":"en","type":"review","venue":"Human Gene Therapy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research","keywords":"CRISPR; Genome editing; Cas9; Muscular dystrophy; Duchenne muscular dystrophy; Biology; Genetic enhancement; Computational biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005481416,0.0008700042,0.0009962147,0.002208544,0.0002195823,0.0007367286,0.0007512512,0.0009957792,0.002879588],"category_scores_gemma":[0.0005424747,0.0002723763,0.000687974,0.001448748,0.0003030578,0.0007515584,0.0005908343,0.001968967,0.001547008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005740602,"about_ca_system_score_gemma":0.0008877859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001170336,"about_ca_topic_score_gemma":0.001569478,"domain_scores_codex":[0.9997738,0.00003275936,0.00003006775,0.00004125663,0.00009695101,0.00002526026],"domain_scores_gemma":[0.9998273,0.00008844801,0.00002268309,0.000005856594,0.00003939696,0.00001631708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006327609,0.00007126579,0.00008403539,0.01587262,0.0001185118,0.0002585004,0.00005476319,0.000673776,0.005802528,0.005311132,0.02515134,0.9465382],"study_design_scores_gemma":[0.00002353784,0.00009659888,0.0004711703,0.002168618,0.0001151414,0.001016872,0.00002460188,0.0001415118,0.001670529,0.00153653,0.9927133,0.00002171191],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001922372,0.9968956,0.0005488672,0.0002563277,0.0002552875,0.00001002955,0.00003480832,0.00002745599,0.001779514],"genre_scores_gemma":[0.0009237065,0.9974257,0.0004910292,0.0002165889,0.00008729611,0.00001177635,0.00005656502,0.000004208367,0.0007830989],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002879588,"threshold_uncertainty_score":0.009633183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05470464303350239,"score_gpt":0.4087134899131489,"score_spread":0.3540088468796465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}