{"id":"W4367368671","doi":"10.1101/2023.04.28.538770","title":"A transposase-derived gene required for human brain development","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University","funders":"LOEWE Zentrum AdRIA; National Institutes of Health; Pershing Square Sohn Cancer Research Alliance; Compute Canada; Canadian Institutes of Health Research; G. Harold and Leila Y. Mathers Foundation","keywords":"Biology; Transposable element; Transposase; Gene; Vertebrate; Genetics; Epigenetics; Somatic cell; Genome; DNA methylation; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004794835,0.0002524891,0.0001431156,0.000224614,0.0001504177,0.0001627066,0.0001135169,0.0002442605,0.0037245],"category_scores_gemma":[0.0001319195,0.00006637429,0.0001714819,0.0002049549,0.000154121,0.00008646361,0.0001619735,0.0002263424,0.000919548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001426874,"about_ca_system_score_gemma":0.0002177281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001022616,"about_ca_topic_score_gemma":0.0008202591,"domain_scores_codex":[0.999947,0.00000408647,0.000004476132,0.00001672916,0.00001860334,0.000009144015],"domain_scores_gemma":[0.9999686,0.000004933079,0.000007946493,0.000004605385,0.000003083914,0.00001074111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001569083,0.000012538,0.001986509,0.00007876663,0.00002594484,0.001373005,0.00004125732,0.00006736464,0.9783046,0.0009462048,0.0005792778,0.01642775],"study_design_scores_gemma":[0.0001012954,0.0003536876,0.1887128,0.00005588002,0.0001089406,0.01892614,0.0001060543,0.001288276,0.7243223,0.001849576,0.06415158,0.0000235022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9605694,0.003370957,0.01528392,0.0003420461,0.0001477533,0.00007990884,0.007302202,0.0007194636,0.01218441],"genre_scores_gemma":[0.9805458,0.0009195456,0.005881304,0.0001067322,0.00002474719,0.00002278644,0.00726087,0.00005635312,0.005181833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0037245,"threshold_uncertainty_score":0.01245964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04210167868242647,"score_gpt":0.2339950409599024,"score_spread":0.1918933622774759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}