{"id":"W4367395482","doi":"10.1093/humrep/dead085","title":"Human organoid systems in modeling reproductive tissue development, function, and disease","year":2023,"lang":"en","type":"review","venue":"Human Reproduction","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"","keywords":"Organoid; Biology; Blastocyst; Trophoblast; Embryonic stem cell; Stem cell; Bioinformatics; Fetus; Cell biology; Pregnancy; Placenta; Embryo; Embryogenesis; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00220998,0.0006077071,0.001842951,0.0007061192,0.0004716616,0.00004527325,0.0001329654,0.0004232464,0.0000267802],"category_scores_gemma":[0.001130472,0.0005328915,0.0001469216,0.000756336,0.0002137784,0.0001506698,0.000163212,0.0008525726,0.0001287654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004260929,"about_ca_system_score_gemma":0.0004170303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001052362,"about_ca_topic_score_gemma":0.00001682897,"domain_scores_codex":[0.9941047,0.0003970146,0.0013849,0.003392413,0.0002941549,0.0004268078],"domain_scores_gemma":[0.9968813,0.00001999508,0.0004479392,0.002093585,0.0003102818,0.0002469194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001622489,0.001905394,0.003330468,0.1844071,0.002435163,0.0003462176,0.001650105,0.0002438841,0.001059618,0.002298692,0.00282575,0.7978751],"study_design_scores_gemma":[0.0009902423,0.0003759128,0.03011619,0.01768892,0.002632734,0.0003655321,0.0002800495,0.00002625604,0.00002639441,0.002882236,0.9430916,0.001523976],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01167067,0.9832057,0.00005905161,0.00008538312,0.001226674,0.003217024,0.000008032452,0.0003889338,0.0001385242],"genre_scores_gemma":[0.01187569,0.9658599,0.00006168598,0.00001589094,0.005149802,0.001074018,0.001178193,0.0002456818,0.01453913],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9402658,"threshold_uncertainty_score":0.9997123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1416601881186915,"score_gpt":0.376135356058704,"score_spread":0.2344751679400125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}