{"id":"W4367396579","doi":"10.52547/nl.2.1.16","title":"Regional cerebral blood flow and brain atrophy in mild cognitive impairment and Alzheimer's disease","year":2023,"lang":"en","type":"article","venue":"Neurology Letters","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; BioClinica; F. Hoffmann-La Roche; University of Southern California; Biogen; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Precuneus; Cerebral blood flow; Supramarginal gyrus; Atrophy; Cardiology; Neuroimaging; Cognitive decline; Entorhinal cortex; Psychology; Brain size; Alzheimer's disease; Neuroscience; Temporal cortex; Medicine; Biomarker; Magnetic resonance imaging; Internal medicine; Dementia; Disease; Cognition; Radiology; Functional magnetic resonance imaging; Hippocampus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004859047,0.0002678352,0.0002299022,0.0009343784,0.0001634914,0.0001934025,0.0001762502,0.0002601731,0.001210596],"category_scores_gemma":[0.0009839995,0.00006377852,0.0001268648,0.0003676665,0.0002825902,0.0001885424,0.0001954506,0.0002262293,0.0001278947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002195142,"about_ca_system_score_gemma":0.0001988478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003824414,"about_ca_topic_score_gemma":0.003248422,"domain_scores_codex":[0.99989,0.00002793475,0.00001019634,0.00002652392,0.00003180528,0.00001350263],"domain_scores_gemma":[0.9996781,0.00006219799,0.0001540123,0.000009999606,0.00004044572,0.00005533671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001449126,0.0003387371,0.9538428,0.0002783843,0.0002661836,0.0004981074,0.000334665,0.0003306902,0.008788911,0.0001595793,0.0004068275,0.03330595],"study_design_scores_gemma":[0.000006286388,0.0001070447,0.9993083,0.000005527392,0.00001295217,0.0001609881,0.00002105479,0.00007270309,0.0001284058,0.00006813649,0.0001066934,0.000001813457],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935557,0.004835871,0.0002103189,0.0000871634,0.00001303363,0.00002055882,0.0002260286,0.00001442268,0.001036876],"genre_scores_gemma":[0.9986085,0.0005570475,0.000285591,0.00004088424,0.0000283098,0.0000167192,0.000173446,0.000001088158,0.0002884063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003824414,"threshold_uncertainty_score":0.007604301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02003047198891843,"score_gpt":0.2850527150800841,"score_spread":0.2650222430911656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}