{"id":"W4367397140","doi":"10.1016/j.arr.2023.101941","title":"Biological resilience and aging: Activation of stress response pathways contributes to lifespan extension","year":2023,"lang":"en","type":"review","venue":"Ageing Research Reviews","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Longevity; Biology; Model organism; Organism; Mutant; Stressor; Mechanism (biology); Cellular stress response; Genetics; Fight-or-flight response; Phenotype; Cell biology; Neuroscience; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.005957351,0.0003796454,0.001363041,0.0003911827,0.0002149158,0.00007655595,0.0006370313,0.0004546484,0.00000603912],"category_scores_gemma":[0.01094118,0.0002865531,0.0002608192,0.0007018638,0.0002887154,0.000005639615,0.0009520893,0.000517085,0.00005581541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000053853,"about_ca_system_score_gemma":0.0002763913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004060072,"about_ca_topic_score_gemma":0.00001990488,"domain_scores_codex":[0.9943088,0.002845849,0.0008861359,0.0009775093,0.0003894156,0.0005922953],"domain_scores_gemma":[0.9974129,0.0007093043,0.0003171823,0.001006496,0.0003416998,0.000212421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001192257,0.00008021903,0.00006907326,0.01196458,0.00009367045,0.00003474452,0.0002315691,0.000006368309,0.06913178,0.00006035153,0.002932749,0.9152757],"study_design_scores_gemma":[0.000120653,0.0004858949,0.0005153685,0.01456264,0.00004830557,0.000007186921,0.00004216518,0.00000497842,0.003999945,0.00007291736,0.9798311,0.0003088293],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01760107,0.9794778,0.0006159066,0.0001294869,0.00008848144,0.001986627,0.00006317591,0.00002100212,0.00001644209],"genre_scores_gemma":[0.003586376,0.9949573,0.0004150845,0.00006400159,0.0001741188,0.0001986854,0.000133674,0.00005905454,0.0004117494],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9768984,"threshold_uncertainty_score":0.9999586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2217480476406425,"score_gpt":0.427129606421499,"score_spread":0.2053815587808565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}