{"id":"W4367556468","doi":"10.1101/2023.04.30.538854","title":"Development of a nucleoside-modified mRNA vaccine against clade 2.3.4.4b H5 highly pathogenic avian influenza virus","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; University of Pennsylvania; Burroughs Wellcome Fund; U.S. Department of Health and Human Services","keywords":"Influenza A virus subtype H5N1; Virology; Hemagglutinin (influenza); Highly pathogenic; Clade; Virus; Biology; Glycoprotein; H5N1 genetic structure; Messenger RNA; Nucleoside; Avian influenza virus; Gene; Microbiology; Coronavirus disease 2019 (COVID-19); Phylogenetics; Medicine; Molecular biology; Infectious disease (medical specialty); Disease; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001224348,0.0002139908,0.0001396096,0.0000843933,0.0001083086,0.0001728716,0.0001327612,0.0002697941,0.0008030437],"category_scores_gemma":[0.0001054281,0.00008588796,0.0001856618,0.0000381319,0.0001338969,0.0001299276,0.0001290984,0.0002905182,0.0003589335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002279163,"about_ca_system_score_gemma":0.0002001375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004286324,"about_ca_topic_score_gemma":0.0004447329,"domain_scores_codex":[0.9999524,0.000005885834,0.000003004292,0.00001172731,0.00001754963,0.000009421903],"domain_scores_gemma":[0.9999781,0.000003652266,0.000005564067,0.00000221279,0.000004797294,0.000005736836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003187255,0.00002127789,0.00009136426,0.00002435106,0.000003281683,0.00003731158,0.0000104211,0.0003144934,0.9962032,0.0001514793,0.00008417536,0.003026775],"study_design_scores_gemma":[0.00002612486,0.0004454314,0.0005823794,0.000004888618,0.00001284288,0.0001007905,0.00001036981,0.002171184,0.9924837,0.00005236953,0.004106611,0.000003199001],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9714894,0.000986748,0.02210935,0.000336748,0.0001514202,0.0001967908,0.0002890699,0.0001485294,0.004291883],"genre_scores_gemma":[0.9629019,0.0008863281,0.02676243,0.0001378001,0.0000313164,0.0001211089,0.0007768967,0.00004782884,0.008334298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008030437,"threshold_uncertainty_score":0.002686501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06923293240145845,"score_gpt":0.3140577967818922,"score_spread":0.2448248643804337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}