{"id":"W4367599067","doi":"10.3390/pharmaceutics15051391","title":"Impacts of PEGylation and Glycosylation on the Biological Properties of Host Defense Peptide IDR1018","year":2023,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"PEGylation; Glycosylation; Peptide; Chemistry; Proinflammatory cytokine; Conjugate; Biochemistry; Lipopolysaccharide; Polyethylene glycol; Inflammation; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002260878,0.00009074972,0.00014547,0.00006009013,0.00009762308,0.000005665824,0.0000678307,0.00007939681,0.00006051972],"category_scores_gemma":[0.0001058723,0.00005434773,0.00004402943,0.0001176151,0.0003211362,0.00004826086,0.00005788451,0.0001274062,0.00004596047],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007729798,"about_ca_system_score_gemma":0.00001584123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004247315,"about_ca_topic_score_gemma":0.000003994527,"domain_scores_codex":[0.9994342,0.0001034948,0.0001812181,0.0001035308,0.00002680205,0.0001507044],"domain_scores_gemma":[0.9995478,0.0001804882,0.0001197189,0.00009343906,0.00004889009,0.000009674398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001551747,0.00003577577,0.007444198,0.00003783602,0.00005150004,4.108823e-7,0.0006380874,0.00001842203,0.9892681,0.001030553,0.0006337602,0.0006861364],"study_design_scores_gemma":[0.0003484101,0.0001318038,0.01964507,0.00005993171,0.0000264671,0.000006948261,0.0004748525,0.00008665465,0.9766979,0.0001124465,0.002335468,0.00007409525],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982795,0.0005829908,0.000009307954,0.0004753304,0.0001167855,0.0001678221,0.00003616425,0.00003316486,0.0002989111],"genre_scores_gemma":[0.9988093,0.0008502202,0.000009382434,0.0001165633,0.00001703005,0.000003343642,0.00001962194,0.000006975394,0.0001675526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0125703,"threshold_uncertainty_score":0.2216236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09044844109285417,"score_gpt":0.2987118723506169,"score_spread":0.2082634312577628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}