{"id":"W4367600266","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2805","title":"Oxidized Phosphatidylcholine Promotes Protein Kinase C-mediated B <sub>2</sub> Adrenoceptor Dysfunction to Induce Bronchodilator Insensitivity","year":2023,"lang":"en","type":"article","venue":"","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Bronchodilator; Protein kinase C; Protein kinase A; Pharmacology; Kinase; Cell biology; Chemistry; Internal medicine; Endocrinology; Medicine; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003199324,0.000427998,0.0003365055,0.0003993027,0.0002988438,0.00044939,0.0003075512,0.0004487145,0.002449659],"category_scores_gemma":[0.0002280653,0.0002474345,0.0006974908,0.0002739334,0.0004156457,0.000281855,0.000384324,0.001283982,0.0004492188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008224354,"about_ca_system_score_gemma":0.000531021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002226882,"about_ca_topic_score_gemma":0.003190083,"domain_scores_codex":[0.9997289,0.00004080067,0.00001761475,0.00002829341,0.00004474288,0.0001396556],"domain_scores_gemma":[0.9998374,0.00003241347,0.00003006617,0.00003301455,0.00001839139,0.00004879602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001535182,0.0001964501,0.0002247503,0.0000262612,0.00001764297,0.0001641585,0.00002055486,0.00008154618,0.9963996,0.0002715043,0.0001071436,0.0009551169],"study_design_scores_gemma":[0.000228478,0.001098405,0.01029359,0.00001243722,0.00003698256,0.0003848438,0.00009192411,0.001417117,0.9847546,0.0001947179,0.0014758,0.00001118606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962625,0.0006762245,0.00088908,0.000168929,0.00008956323,0.00004137116,0.0002725206,0.00004332478,0.001556532],"genre_scores_gemma":[0.9969839,0.000427092,0.0005909229,0.00009995294,0.0000141909,0.0000320532,0.0003251894,0.00001546643,0.001511239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002449659,"threshold_uncertainty_score":0.008194923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01874473042229097,"score_gpt":0.2480491831147038,"score_spread":0.2293044526924128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}