{"id":"W4367600989","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a3958","title":"The mTOR Strikes Back: Vaping Liquid Induced mTOR Hyperactivation in Lymphangioleiomyomatosis (LAM) Exacerbates Endothelial Cell Apoptosis and Impairment of Network Formation Via Senescence Associated Secretory Phenotype (SASP) Factors","year":2023,"lang":"en","type":"article","venue":"","topic":"Tuberous Sclerosis Complex Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; CReATe Fertility Centre","funders":"","keywords":"PI3K/AKT/mTOR pathway; Lymphangioleiomyomatosis; Hyperactivation; Apoptosis; Senescence; Sirolimus; Phenotype; Cancer research; Medicine; Cell biology; Biology; Internal medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009393156,0.00025439,0.0004157397,0.0002818891,0.0002606881,0.00005732265,0.0001667257,0.0001703433,0.00009132121],"category_scores_gemma":[0.0002687072,0.0001886387,0.00009725771,0.0009645746,0.00008002728,0.0003286825,0.000164622,0.0001914069,0.00002716204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004521433,"about_ca_system_score_gemma":0.0001452221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005797411,"about_ca_topic_score_gemma":0.0001468318,"domain_scores_codex":[0.9974716,0.0002939856,0.0006207731,0.0003271347,0.0006439217,0.0006426295],"domain_scores_gemma":[0.9979947,0.001055057,0.0002767426,0.0003024349,0.0002265364,0.0001445373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004289397,0.0001540728,0.04523759,0.0001548836,0.00007311546,7.280807e-7,0.001881726,0.00009184706,0.9506266,0.00003406167,0.0003211712,0.0009952679],"study_design_scores_gemma":[0.002418868,0.0008609849,0.2722162,0.0004039042,0.00005113131,0.00000182566,0.002624542,0.0124226,0.7086024,0.00004293959,0.00007603796,0.0002784769],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977869,0.00009863918,0.000195302,0.0003475605,0.0001744079,0.0009914419,0.00001315345,0.0001307313,0.000261795],"genre_scores_gemma":[0.9990366,0.0002521448,0.0001697641,0.00005756849,0.0001101849,0.00006384138,0.00009666324,0.00004206804,0.0001711488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2420241,"threshold_uncertainty_score":0.7692462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03959325360053997,"score_gpt":0.2707407085955245,"score_spread":0.2311474549949845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}