{"id":"W4367600989","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a3958","title":"The mTOR Strikes Back: Vaping Liquid Induced mTOR Hyperactivation in Lymphangioleiomyomatosis (LAM) Exacerbates Endothelial Cell Apoptosis and Impairment of Network Formation Via Senescence Associated Secretory Phenotype (SASP) Factors","year":2023,"lang":"en","type":"article","venue":"","topic":"Tuberous Sclerosis Complex Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; CReATe Fertility Centre","funders":"","keywords":"PI3K/AKT/mTOR pathway; Lymphangioleiomyomatosis; Hyperactivation; Apoptosis; Senescence; Sirolimus; Phenotype; Cancer research; Medicine; Cell biology; Biology; Internal medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001990129,0.0003524825,0.0003413798,0.0003192045,0.0002990792,0.0004691033,0.0003195623,0.0005783312,0.003688883],"category_scores_gemma":[0.0001917035,0.0002008214,0.0005536819,0.0001630556,0.0005615812,0.0004264757,0.0003477895,0.001384905,0.0005903696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003832678,"about_ca_system_score_gemma":0.0002833685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006378152,"about_ca_topic_score_gemma":0.001005012,"domain_scores_codex":[0.9997243,0.00005734771,0.0000227166,0.00004274024,0.00006663435,0.00008621317],"domain_scores_gemma":[0.9998711,0.00001194927,0.00004438102,0.0000128838,0.00001190103,0.00004780079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001032704,0.0001440751,0.0003649854,0.00008353133,0.00002273663,0.000262553,0.00002506311,0.00006184389,0.9949191,0.0002819688,0.0003302094,0.002471201],"study_design_scores_gemma":[0.0002172379,0.002085652,0.0184067,0.00004102881,0.00009145799,0.001206358,0.0003000783,0.001926775,0.969522,0.0005610487,0.00562132,0.00002031717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932957,0.002088176,0.001703708,0.0009297788,0.0001469552,0.00002342509,0.0003058235,0.0001936492,0.001312733],"genre_scores_gemma":[0.9969765,0.0004850786,0.0005813789,0.000156144,0.00002754734,0.00002765735,0.0001337462,0.00002017445,0.001591711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003688883,"threshold_uncertainty_score":0.01234049,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03959325360053997,"score_gpt":0.2707407085955245,"score_spread":0.2311474549949845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}