{"id":"W4367601287","doi":"10.1158/1078-0432.ccr-23-0411","title":"Efficacy of Nivolumab in Pediatric Cancers with High Mutation Burden and Mismatch Repair Deficiency","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Hospital for Sick Children; BC Children's Hospital; University of Toronto","funders":"Hospital for Sick Children; Stand Up To Cancer; St. Baldrick's Foundation","keywords":"Nivolumab; Medicine; Mutation; Refractory (planetary science); Oncology; Internal medicine; Cancer research; Cancer; Immunotherapy; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000882339,0.0003580685,0.0007282485,0.0001264708,0.0001621556,0.0004001708,0.000263409,0.0002747269,0.0007435625],"category_scores_gemma":[0.0008540091,0.0001162423,0.0004561848,0.000169197,0.0002808116,0.0002803663,0.0001887118,0.0007532075,0.000129293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007932792,"about_ca_system_score_gemma":0.001067307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008332613,"about_ca_topic_score_gemma":0.002799733,"domain_scores_codex":[0.9996611,0.0001806095,0.00002626746,0.00004354166,0.00004101825,0.00004751272],"domain_scores_gemma":[0.9994515,0.0002022235,0.0001732381,0.00002965319,0.00003781569,0.0001057174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1860105,0.005632782,0.3671626,0.002742566,0.00224273,0.00164351,0.0004334949,0.005713413,0.07151102,0.0006375842,0.003708774,0.3525611],"study_design_scores_gemma":[0.06172265,0.3139298,0.5111167,0.001025609,0.003113944,0.01356459,0.0005894207,0.005716935,0.05911213,0.0006340007,0.02942081,0.00005340496],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924154,0.006132368,0.0002564299,0.0001524205,0.00001840267,0.0001245588,0.0002201123,0.00001514921,0.0006652129],"genre_scores_gemma":[0.996978,0.001617407,0.0006586188,0.0001548058,0.00002609731,0.00008166529,0.0003098378,0.000006749979,0.0001667849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000882339,"threshold_uncertainty_score":0.005755663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1247963977147627,"score_gpt":0.4762200490703872,"score_spread":0.3514236513556246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}