{"id":"W4367601927","doi":"10.1002/cmdc.202300128","title":"Scalable and Chromatography‐Free Synthesis of Efflux Pump Inhibitor Phenylalanine Arginine β‐Naphthylamide for Its Validation in Wild‐Type Bacterial Strains","year":2023,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Chemistry; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; University of British Columbia; Villanova University; National Institutes of Health; National Science Foundation","keywords":"Dipeptide; Efflux; Phenylalanine; Enantiomer; Chemistry; Stereochemistry; Peptide; Chromatography; Amino acid; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002856293,0.0002019986,0.0003046287,0.0001108873,0.00003929673,0.00002431925,0.0002122915,0.0002146316,0.00002951331],"category_scores_gemma":[0.0005932919,0.0002057578,0.00007981047,0.0003331651,0.0001263051,0.00001288797,0.0001258224,0.00005691432,0.000004655046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001563908,"about_ca_system_score_gemma":0.00006483903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006171692,"about_ca_topic_score_gemma":0.00001641983,"domain_scores_codex":[0.9987523,0.00002903231,0.0003612459,0.0004077508,0.0001272188,0.0003224335],"domain_scores_gemma":[0.9992316,0.00006462432,0.0001495745,0.000375572,0.0001060484,0.00007255845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001784168,0.00005696975,0.009646728,0.0002577949,0.00004966203,0.000001548997,0.00003828793,0.000003549658,0.9872876,0.00004264014,0.002023215,0.0004135456],"study_design_scores_gemma":[0.001024157,0.0001289517,0.02310103,0.0001093051,0.00002387646,0.000005022223,0.00007859419,0.00005543366,0.974348,0.00009655943,0.0008269218,0.0002021381],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986804,0.00008523701,0.00003375066,0.0001492572,0.0002205683,0.0003658617,0.0001382442,0.00002906549,0.0002976171],"genre_scores_gemma":[0.9978406,0.0002073064,0.0007769635,0.00001372775,0.0003221762,0.00003856736,0.0004562275,0.00004219045,0.0003022622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01345431,"threshold_uncertainty_score":0.8390559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01426429216157069,"score_gpt":0.2508963985730098,"score_spread":0.2366321064114391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}