{"id":"W4367602100","doi":"10.1016/j.jconrel.2023.04.046","title":"A bionic “Trojan horse”-like gene delivery system hybridized with tumor and macrophage cell membrane for cancer therapy","year":2023,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"York University","funders":"Fundamental Research Funds for the Central Universities; China Postdoctoral Science Foundation","keywords":"Cancer research; Genetic enhancement; Antagomir; Gene delivery; Cancer cell; microRNA; Cell; Immune system; Biology; Cancer; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002565594,0.0002902923,0.0001921417,0.0001990903,0.0002574926,0.0002385322,0.0002586086,0.0004384207,0.0008570358],"category_scores_gemma":[0.0001059823,0.000194024,0.0002188405,0.0001209908,0.0002276985,0.000242977,0.0001988512,0.0004310975,0.0002789613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002297949,"about_ca_system_score_gemma":0.0002480316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002416227,"about_ca_topic_score_gemma":0.000396234,"domain_scores_codex":[0.9998893,0.0000303441,0.000005016749,0.00002661644,0.00002351874,0.00002533459],"domain_scores_gemma":[0.9999386,0.00001541035,0.00001620535,0.000008813151,0.000009738742,0.00001114644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001769396,0.000004449176,0.00001705401,0.00001440019,0.000001763333,0.00002009468,0.000008945708,0.00003248703,0.9991369,0.0001683888,0.00001702316,0.0005608384],"study_design_scores_gemma":[0.000004658048,0.0001320745,0.0002158312,0.000002152869,0.0000123723,0.0001047295,0.000005863656,0.0004122587,0.996885,0.00002676473,0.002195608,0.000002682262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9463299,0.001813899,0.04702735,0.0002527537,0.0001298034,0.00009837419,0.00009524484,0.0004208291,0.003831718],"genre_scores_gemma":[0.9664688,0.0007862521,0.02709429,0.0001420323,0.00002584171,0.00007012251,0.0001706134,0.00007041905,0.0051716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008570358,"threshold_uncertainty_score":0.002867043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007591911471866395,"score_gpt":0.2292641913875088,"score_spread":0.2216722799156424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}