{"id":"W4367603663","doi":"10.1158/2643-3249.aml23-a16","title":"Abstract A16: Multi-omic analyses in genetically engineered mice reveal distinct and opposite effects of leukemogenic Idh and Tet2 mutations in hematopoietic stem and progenitor cells","year":2023,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Princess Margaret Cancer Centre","funders":"","keywords":"Biology; IDH2; Haematopoiesis; Isocitrate dehydrogenase; Epigenetics; Progenitor cell; Myeloid; DNA methylation; Myeloid leukemia; Stem cell; Cancer research; IDH1; Genetics; Mutation; Gene; Gene expression; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002684058,0.0008029799,0.0003760112,0.001505535,0.0003047173,0.0005746211,0.0004585425,0.0008828907,0.004995871],"category_scores_gemma":[0.0001322899,0.0003184868,0.000683303,0.0003661696,0.0006942906,0.0002458388,0.0005763991,0.001575731,0.001134179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004310314,"about_ca_system_score_gemma":0.0002167876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005797474,"about_ca_topic_score_gemma":0.0009180348,"domain_scores_codex":[0.9994186,0.0000496889,0.00006953086,0.0001893808,0.0001677633,0.00010503],"domain_scores_gemma":[0.9995314,0.00006699837,0.0001777924,0.00003939206,0.00002438383,0.0001599954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000971672,0.00003183671,0.0001427459,0.00001734025,0.000008070318,0.0001035687,0.0000138842,0.00004094797,0.9989041,0.0001351788,0.00003169841,0.000473302],"study_design_scores_gemma":[0.0000361819,0.0002540696,0.007038185,0.00001352276,0.00003668869,0.000817234,0.00005727198,0.0008079842,0.9883829,0.0001179418,0.00242692,0.00001121889],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794362,0.0007825484,0.009954773,0.0002484489,0.0001135323,0.0001032275,0.006431021,0.0004367367,0.002493548],"genre_scores_gemma":[0.9720651,0.0005998255,0.006882187,0.0002536389,0.0000307541,0.0002023351,0.004689219,0.0005296097,0.01474722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004995871,"threshold_uncertainty_score":0.0167129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02629545926025301,"score_gpt":0.3194442679006793,"score_spread":0.2931488086404263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}