{"id":"W4367603727","doi":"10.1158/2643-3249.aml23-a54","title":"Abstract A54: Polyamines are required for AML LSC function through their role in regulating eIF5A dependent protein synthesis","year":2023,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Arginine; Haematopoiesis; Myeloid leukemia; Stem cell; Progenitor cell; Biology; Leukemia; Cancer research; Polyamine; Metabolite; Biochemistry; Myeloid; Cell biology; Immunology; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000815376,0.000206031,0.0002107639,0.0001405214,0.0002150367,0.0003362335,0.000145181,0.0002932906,0.006192576],"category_scores_gemma":[0.0001309795,0.00008615424,0.0002438331,0.0001489433,0.000178909,0.0001946527,0.000201926,0.0004612366,0.0009465939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003177577,"about_ca_system_score_gemma":0.0002414935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006757788,"about_ca_topic_score_gemma":0.0009029412,"domain_scores_codex":[0.9999017,0.00000908117,0.00001192111,0.00003019391,0.00003009564,0.00001709625],"domain_scores_gemma":[0.9999003,0.0000128326,0.00003072078,0.000009060949,0.00001494931,0.0000321366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003522792,0.00002158557,0.0008775198,0.00004850449,0.000006389111,0.00009529117,0.00001058582,0.00004450675,0.9956428,0.00006868391,0.0002420368,0.002589752],"study_design_scores_gemma":[0.00004612351,0.0005270697,0.04182289,0.00002260325,0.00003425658,0.0006334537,0.00007433193,0.0006711399,0.9444575,0.0001322106,0.01157156,0.000006899626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870249,0.003361526,0.002260933,0.0004581976,0.0001284328,0.00003193484,0.002946927,0.0002010732,0.003586011],"genre_scores_gemma":[0.9901939,0.0009438097,0.001542703,0.0002053424,0.00001930569,0.00002883019,0.002601383,0.00003612848,0.004428566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006192576,"threshold_uncertainty_score":0.02071619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01811990868516516,"score_gpt":0.2624131206114914,"score_spread":0.2442932119263262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}