{"id":"W4367603727","doi":"10.1158/2643-3249.aml23-a54","title":"Abstract A54: Polyamines are required for AML LSC function through their role in regulating eIF5A dependent protein synthesis","year":2023,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Arginine; Haematopoiesis; Myeloid leukemia; Stem cell; Progenitor cell; Biology; Leukemia; Cancer research; Polyamine; Metabolite; Biochemistry; Myeloid; Cell biology; Immunology; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001370918,0.0001881246,0.0001988397,0.00005270962,0.0001090409,0.00005319097,0.0001749391,0.0001234705,0.000008111712],"category_scores_gemma":[0.00007647478,0.0001694718,0.0001137365,0.0002045572,0.00003985424,0.00003223132,0.00008516668,0.00006038387,0.000005011389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001582954,"about_ca_system_score_gemma":0.00008798583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003595185,"about_ca_topic_score_gemma":0.0006924477,"domain_scores_codex":[0.9988176,0.00002402187,0.0002636724,0.0004480322,0.0001152841,0.0003314475],"domain_scores_gemma":[0.9993604,0.0000295069,0.000160685,0.0003755555,0.00003671952,0.00003711149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001125024,0.0001040639,0.002134911,0.00007367789,0.00007471777,7.722181e-7,0.00004943836,0.0001870953,0.9880185,0.0001575253,0.000450469,0.008636324],"study_design_scores_gemma":[0.0007110036,0.00004592751,0.05507877,0.0001161252,0.00006969582,0.000001551552,0.0006288111,0.000057794,0.9353946,0.0009917113,0.00662492,0.000279078],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940736,0.003468005,0.0004645335,0.0003852192,0.0001321018,0.0006253176,0.0005237172,0.0000402521,0.0002872954],"genre_scores_gemma":[0.9948194,0.0003663981,0.0001202776,0.00008926792,0.0006233049,0.002320069,0.0001968842,0.00004074015,0.001423665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05294386,"threshold_uncertainty_score":0.6910859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01811990868516516,"score_gpt":0.2624131206114914,"score_spread":0.2442932119263262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}