{"id":"W4367607045","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a3983","title":"GS-441524 Parent Nucleoside to Remdesivir Can Effectively Inhibits Sars-Cov-2 Omicron Infections in Human Lung Organoids","year":2023,"lang":"en","type":"article","venue":"","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre; St. Michael's Hospital; University of Toronto","funders":"","keywords":"Organoid; Virology; Coronavirus disease 2019 (COVID-19); Human lung; Lung; Nucleoside; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Lung infection; Medicine; Biology; Cell biology; Internal medicine; Genetics; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001506819,0.0004372956,0.000549364,0.0003188058,0.0001874841,0.0002971822,0.0003683581,0.0003785534,0.002496334],"category_scores_gemma":[0.0001285474,0.0001572772,0.0003471022,0.000203107,0.0002279148,0.0002227009,0.0001523301,0.0007429399,0.0005991606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003286595,"about_ca_system_score_gemma":0.0004836586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002694797,"about_ca_topic_score_gemma":0.003572228,"domain_scores_codex":[0.9998516,0.00003425235,0.00001182909,0.00002735976,0.00002567745,0.00004931201],"domain_scores_gemma":[0.9999614,0.000009270898,0.000004897367,0.000007946483,0.000005197602,0.00001131635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009245175,0.0003406477,0.0001707681,0.0001073379,0.00002652485,0.0001145052,0.00004734478,0.000399805,0.9916386,0.0002378864,0.0004145613,0.005577506],"study_design_scores_gemma":[0.0001418567,0.002295608,0.001971692,0.000008149935,0.00004304302,0.0001932756,0.00004235994,0.0007856518,0.9898873,0.000040163,0.004582057,0.000008893466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905759,0.002247397,0.0009818126,0.000101831,0.0001388755,0.00009026875,0.0007625312,0.0001454466,0.004955931],"genre_scores_gemma":[0.9923002,0.0010164,0.001067545,0.00005368813,0.00001815639,0.0000600221,0.001240131,0.00001999389,0.004223926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002694797,"threshold_uncertainty_score":0.008351088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.025666816857681,"score_gpt":0.3430767424424643,"score_spread":0.3174099255847833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}