{"id":"W4367608668","doi":"10.1016/j.exphem.2023.04.004","title":"MST1 downregulates TAZ tumor suppressor protein in multiple myeloma and is a potential therapeutic target","year":2023,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Saint John Regional Hospital; University of New Brunswick","funders":"Canadian Institutes of Health Research; New Brunswick Innovation Foundation; Fondation de la recherche en santé du Nouveau-Brunswick","keywords":"Cancer research; Multiple myeloma; Hippo signaling pathway; Suppressor; Downregulation and upregulation; Kinase; Lenalidomide; Signal transduction; Medicine; Biology; Cancer; Immunology; Cell biology; Gene; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001154323,0.0002162702,0.0002612905,0.00009490849,0.0001006416,0.00002297958,0.0001519036,0.0001751092,0.0001022955],"category_scores_gemma":[0.00002149618,0.0002068061,0.00007348081,0.0001213977,0.0001694895,0.000006436418,0.000166253,0.00009943809,0.00006562484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001148265,"about_ca_system_score_gemma":0.00003407396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003334833,"about_ca_topic_score_gemma":0.000009383793,"domain_scores_codex":[0.9986332,0.00009922861,0.0002514791,0.0004906859,0.0001054419,0.00041995],"domain_scores_gemma":[0.9995708,0.00001447829,0.00006029142,0.0002460452,0.00002075136,0.00008767572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001680651,0.0001138464,0.001551889,0.00002515071,0.00003242017,0.0000929313,0.0004662483,0.000009480226,0.9969094,0.000359289,0.0001697706,0.0001014971],"study_design_scores_gemma":[0.001140699,0.0002746194,0.0009331402,0.00002116109,0.000004012146,0.0001754933,0.0006827674,0.0008172102,0.9940454,0.0002265685,0.001440429,0.0002384357],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937444,0.005320458,0.0000375496,0.0002177592,0.0001146039,0.0003762851,0.00003109745,0.00005155466,0.0001062303],"genre_scores_gemma":[0.9984679,0.00000919127,0.0004674919,0.0002383985,0.00007052249,0.0001927933,0.0001172855,0.00003548023,0.0004009602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005311267,"threshold_uncertainty_score":0.8433309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01200988772958877,"score_gpt":0.2561280661371215,"score_spread":0.2441181784075327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}