{"id":"W4367608930","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a4493","title":"Alvelestat, an Oral Neutrophil Elastase Inhibitor in Alpha-1 Antitrypsin Deficiency (AATD): Results of a Phase II Trial","year":2023,"lang":"en","type":"article","venue":"","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital","funders":"","keywords":"Neutrophil elastase; Alpha 1-antitrypsin deficiency; Medicine; Elastase; Alpha (finance); Internal medicine; Pharmacology; Chemistry; Biochemistry; Inflammation; Surgery; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001277061,0.001323273,0.001943904,0.0002804668,0.0002710634,0.00097743,0.00050592,0.00134626,0.002059797],"category_scores_gemma":[0.0008259081,0.0002581464,0.001569557,0.0002967346,0.0005550333,0.0006439351,0.0001611799,0.002535131,0.0005089287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000613189,"about_ca_system_score_gemma":0.0007865498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009637107,"about_ca_topic_score_gemma":0.001780981,"domain_scores_codex":[0.9997163,0.000121381,0.00001556328,0.00003866353,0.0000374258,0.00007056322],"domain_scores_gemma":[0.999415,0.0002067753,0.00006676459,0.00004122111,0.0000415917,0.000228649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7321811,0.01329478,0.005948799,0.001361039,0.003249438,0.0004548299,0.0002227731,0.003005537,0.03185986,0.0006444754,0.008438108,0.1993393],"study_design_scores_gemma":[0.7836207,0.1858283,0.01506896,0.0001355782,0.001429318,0.0006970413,0.00007940016,0.001564252,0.003552696,0.0005176431,0.007457974,0.00004825159],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.965402,0.02377167,0.001391461,0.001701829,0.000453469,0.0008984292,0.001960437,0.0002149384,0.0042058],"genre_scores_gemma":[0.9719844,0.01363208,0.001873282,0.002071225,0.0003989717,0.00093016,0.004120168,0.0000515928,0.004938116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002059797,"threshold_uncertainty_score":0.006890655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02358712654697795,"score_gpt":0.3086044242593117,"score_spread":0.2850172977123338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}