{"id":"W4367625035","doi":"10.1186/s12950-023-00340-3","title":"First trimester human umbilical cord perivascular cells (HUCPVC) modulate the kynurenine pathway and glutamate neurotransmission in an LPS-induced mouse model of neuroinflammation","year":2023,"lang":"en","type":"article","venue":"Journal of Inflammation","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; CReATe Fertility Centre","funders":"Hospital for Sick Children","keywords":"Glutamatergic; Neuroprotection; Neuroinflammation; Neurotoxicity; Kynurenine pathway; Glutamate receptor; Pharmacology; Indoleamine 2,3-dioxygenase; Microglia; Kynurenine; Lipopolysaccharide; Medicine; Biology; Biochemistry; Receptor; Immunology; Inflammation; Internal medicine; Toxicity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001929823,0.0002569334,0.0002852673,0.000271717,0.0001127914,0.0002388098,0.0001364048,0.0003544553,0.001341646],"category_scores_gemma":[0.0001885053,0.00007846377,0.0002238183,0.0002081526,0.0002051168,0.0001701266,0.0001638461,0.0006053547,0.0002766866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001923313,"about_ca_system_score_gemma":0.0002024207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007188335,"about_ca_topic_score_gemma":0.0008543659,"domain_scores_codex":[0.9998161,0.00002671491,0.000019274,0.0000296841,0.00006561469,0.00004252217],"domain_scores_gemma":[0.9998455,0.00002784967,0.00004232194,0.00001897296,0.00002985304,0.00003553646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008765195,0.0001815628,0.0007415037,0.0001820386,0.00001805709,0.0002397988,0.0000686034,0.0001192191,0.9875659,0.0001897037,0.000218762,0.009598471],"study_design_scores_gemma":[0.00003321315,0.001334114,0.00453275,0.00002229647,0.00004290234,0.0004946719,0.00005272711,0.0004010959,0.9886685,0.00005272082,0.004359313,0.000005756375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818425,0.008527397,0.005760691,0.0002173548,0.0001718765,0.000126516,0.0008034022,0.0001562414,0.002394029],"genre_scores_gemma":[0.9890281,0.0030123,0.003789566,0.0001483471,0.00004880268,0.000132898,0.0008366303,0.00002104336,0.002982261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001341646,"threshold_uncertainty_score":0.00448823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04612519532617023,"score_gpt":0.2749323025495519,"score_spread":0.2288071072233817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}