{"id":"W4367625901","doi":"10.3389/fimmu.2023.930086","title":"Interferon regulatory factor 3 mediates effective antiviral responses to human coronavirus 229E and OC43 infection","year":2023,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Memorial University of Newfoundland","funders":"Institute of Medical Science, University of Tokyo; Faculty of Medicine, Memorial University of Newfoundland; Memorial University of Newfoundland; Natural Sciences and Engineering Research Council of Canada; University of Tokyo; Japan Agency for Medical Research and Development; Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; University of Ottawa","keywords":"IRF3; IRF7; IRF1; Interferon regulatory factors; Biology; Coronavirus; Gene knockdown; Interferon; Virology; Transcription factor; Gene; Coronavirus disease 2019 (COVID-19); Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001808997,0.0002719272,0.0002862473,0.0001461144,0.0002240108,0.0002833637,0.0000977415,0.0002807862,0.001476796],"category_scores_gemma":[0.0001327272,0.00008357051,0.0004128259,0.0000747699,0.0002016399,0.0001776951,0.0002315539,0.0004717753,0.0004270367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002943509,"about_ca_system_score_gemma":0.0002898656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005634758,"about_ca_topic_score_gemma":0.0006812321,"domain_scores_codex":[0.9998481,0.00001840989,0.000008147576,0.00002407412,0.00002943323,0.0000718121],"domain_scores_gemma":[0.9999394,0.000008824377,0.00001358528,0.00000772454,0.000008702595,0.0000217347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001565502,0.00002573499,0.0003805749,0.00003357238,0.000002794515,0.00007728922,0.00001682126,0.00003059168,0.9978362,0.000118969,0.00006425934,0.001256792],"study_design_scores_gemma":[0.00005695249,0.0005565285,0.03729438,0.00002556608,0.00002884893,0.0009484173,0.0001872274,0.001381415,0.9498391,0.0003194302,0.009347408,0.00001470936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937973,0.001763273,0.001322812,0.0001017306,0.00003598464,0.0000243761,0.0002539248,0.00005875443,0.002641869],"genre_scores_gemma":[0.996537,0.0005006763,0.0008407337,0.00006725013,0.00001184071,0.00002163135,0.0005603574,0.00001280245,0.001447666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001476796,"threshold_uncertainty_score":0.004940391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03204273143336066,"score_gpt":0.3520634560242021,"score_spread":0.3200207245908414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}