{"id":"W4367668438","doi":"10.1093/eurheartj/ehad197","title":"2023 Update on European Atherosclerosis Society Consensus Statement on Homozygous Familial Hypercholesterolaemia: new treatments and clinical guidance","year":2023,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":331,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université du Québec à Chicoutimi; Western University","funders":"Esperion Therapeutics; Silence Therapeutics; GlaxoSmithKline; HLS Therapeutics; Swedish Orphan Biovitrum; Servier; Daiichi-Sankyo; Amryt Pharma; Astellas Pharma; Regeneron Pharmaceuticals; Mylan; Ionis Pharmaceuticals; AstraZeneca; Amarin Corporation; REGENXBIO; Danone; Alexion Pharmaceuticals; Kowa Company; Sanofi; Amgen; Pfizer; Eli Lilly and Company; Ironwood Pharmaceuticals, Incorporated; Medpace; Ultragenyx Pharmaceutical","keywords":"Medicine; Familial hypercholesterolemia; Genetic testing; Statement (logic); Lipoprotein(a); Intensive care medicine; Family medicine; Physical therapy; Pediatrics; Internal medicine; Lipoprotein; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004352803,0.0003052319,0.0005309538,0.00008936738,0.0004082164,0.0001251491,0.0001284671,0.0000615075,0.00004684477],"category_scores_gemma":[0.0001352388,0.0002339467,0.0006089841,0.0002151147,0.0001122504,0.0000491048,0.0001149092,0.0009440922,0.001984176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001595456,"about_ca_system_score_gemma":0.0001685672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002429771,"about_ca_topic_score_gemma":0.000002671215,"domain_scores_codex":[0.99598,0.001428517,0.0007710995,0.0005266923,0.0007252074,0.0005685316],"domain_scores_gemma":[0.9982353,0.00009596308,0.000173956,0.0005817153,0.00007905378,0.0008340206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.0009264585,0.0007809251,0.06455153,0.00009676618,0.001637438,0.004079245,0.0007730869,0.00009222431,0.001571743,0.00001740819,0.6892322,0.2362409],"study_design_scores_gemma":[0.006588146,0.002512787,0.8182342,0.0004427622,0.0001781398,0.0009541886,0.0001419956,0.00004546343,0.00005144898,0.000007031028,0.1706325,0.0002113049],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889686,0.0003444825,0.00003915612,0.00540735,0.0007293046,0.0004532204,0.00003186762,0.0001385738,0.003887462],"genre_scores_gemma":[0.9599555,0.01115555,0.002156489,0.0130707,0.00552638,0.000004449753,0.00003961935,0.0002635484,0.007827778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7536827,"threshold_uncertainty_score":0.9987929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.101228137989068,"score_gpt":0.3599020968927974,"score_spread":0.2586739589037294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}