{"id":"W4367669345","doi":"10.1093/hmg/ddad062","title":"Activation of the cGAS-STING innate immune response in cells with deficient mitochondrial topoisomerase TOP1MT","year":2023,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia; Alberta Children's Hospital; University of Calgary","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Alberta Children's Hospital Research Institute; Alberta Children's Hospital Foundation; Natural Sciences and Engineering Research Council of Canada; Lupus Canada; National Cancer Institute; National Institutes of Health; Children's Hospital Foundation; American College Health Foundation; BC Children's Hospital; Center for Cancer Research","keywords":"Biology; Innate immune system; Mitochondrial DNA; Stimulator of interferon genes; Sting; Cell biology; Interferon; Mitochondrion; Immune system; Immunology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001358521,0.0004141076,0.0003568915,0.0001616379,0.0001721549,0.0003338089,0.0002189442,0.0003697888,0.001097122],"category_scores_gemma":[0.0001580799,0.0001214276,0.0003239157,0.0001996876,0.0003031528,0.0001688346,0.0002155925,0.0007742223,0.0004509993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003582296,"about_ca_system_score_gemma":0.0001948702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000715824,"about_ca_topic_score_gemma":0.0006521654,"domain_scores_codex":[0.9998074,0.00003291975,0.00003286974,0.00004383086,0.00004982014,0.00003310632],"domain_scores_gemma":[0.9998251,0.00003639503,0.00006091434,0.00003019534,0.00001041571,0.00003713842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005931769,0.00001428989,0.0001324921,0.00001250903,0.000003998044,0.00008628797,0.00000999538,0.00002902812,0.9993005,0.00003939219,0.00001532407,0.0002967464],"study_design_scores_gemma":[0.00001689138,0.0002571212,0.002980142,0.000003450424,0.00001295473,0.0006630291,0.00003317173,0.001150808,0.9935301,0.00003946561,0.001307745,0.000005054022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956049,0.0003485666,0.002625936,0.00009166536,0.00003384968,0.00002753094,0.0007479711,0.00006849461,0.0004511867],"genre_scores_gemma":[0.9968899,0.0001852687,0.001163667,0.00003176363,0.000007672862,0.00002402839,0.0007047093,0.00001942285,0.0009735308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001097122,"threshold_uncertainty_score":0.003670216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01207276859676911,"score_gpt":0.2439590164045179,"score_spread":0.2318862478077488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}