{"id":"W4367669345","doi":"10.1093/hmg/ddad062","title":"Activation of the cGAS-STING innate immune response in cells with deficient mitochondrial topoisomerase TOP1MT","year":2023,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia; Alberta Children's Hospital; University of Calgary","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Alberta Children's Hospital Research Institute; Alberta Children's Hospital Foundation; Natural Sciences and Engineering Research Council of Canada; Lupus Canada; National Cancer Institute; National Institutes of Health; Children's Hospital Foundation; American College Health Foundation; BC Children's Hospital; Center for Cancer Research","keywords":"Biology; Innate immune system; Mitochondrial DNA; Stimulator of interferon genes; Sting; Cell biology; Interferon; Mitochondrion; Immune system; Immunology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002572243,0.0001419059,0.0001819451,0.0002014065,0.0001274567,0.00001223834,0.0002597728,0.000125391,0.00005578283],"category_scores_gemma":[0.0001030218,0.0001067994,0.00007872737,0.0003797623,0.0001697596,0.00001858395,0.0001489109,0.0002284812,0.00005292191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003946804,"about_ca_system_score_gemma":0.00007246625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004372049,"about_ca_topic_score_gemma":0.000007832878,"domain_scores_codex":[0.9985853,0.0005430941,0.0003279274,0.0001992548,0.00006663871,0.0002778071],"domain_scores_gemma":[0.999261,0.0001080929,0.0001372571,0.0004155402,0.00006875465,0.000009419355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001402016,0.00005867128,0.0001566136,0.00001155389,0.00003361182,0.000009578798,0.000787226,0.001151126,0.9959665,0.000166901,0.0000709263,0.0001852553],"study_design_scores_gemma":[0.001114717,0.0003815492,0.03752793,0.00009221212,0.00001483669,0.000008757842,0.0003429328,0.00002520456,0.9593174,0.00004651031,0.001004867,0.0001231176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985545,0.0004298692,0.0001267027,0.0001213137,0.0003081346,0.000287041,0.000006726871,0.00002746289,0.0001382112],"genre_scores_gemma":[0.9989239,0.00001427855,0.00006291889,0.00005863069,0.000006633227,0.00001580375,0.00001929162,0.00002155929,0.000876997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03737131,"threshold_uncertainty_score":0.4355154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01207276859676911,"score_gpt":0.2439590164045179,"score_spread":0.2318862478077488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}