{"id":"W4367669578","doi":"10.1089/neu.2022.0499","title":"Riluzole in Spinal Cord Injury Study (RISCIS)–Pharmacokinetic (PK) Sub-Study: An Analysis of Pharmacokinetics, Pharmacodynamics, and Impact on Axonal Degradation of Riluzole in Patients With Traumatic Cervical Spinal Cord Injury Enrolled in the RISCIS Phase III Randomized Controlled Trial","year":2023,"lang":"en","type":"article","venue":"Journal of Neurotrauma","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital","funders":"","keywords":"Riluzole; Medicine; Amyotrophic lateral sclerosis; Spinal cord injury; Anesthesia; Traumatic brain injury; Placebo; Pharmacokinetics; Pharmacology; Internal medicine; Spinal cord; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002918736,0.002339056,0.004048354,0.0005030499,0.0003389064,0.001119709,0.0009144421,0.00108221,0.00286739],"category_scores_gemma":[0.002233521,0.0005584054,0.003017009,0.0005479972,0.0009671153,0.0009284822,0.0004196723,0.003148085,0.0007948148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001067355,"about_ca_system_score_gemma":0.00218438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007986618,"about_ca_topic_score_gemma":0.002120683,"domain_scores_codex":[0.9990095,0.0004330408,0.00009079772,0.000195221,0.0001519177,0.0001195049],"domain_scores_gemma":[0.9987026,0.0001778442,0.0005173379,0.0001517857,0.0001652139,0.0002852015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9462597,0.01042119,0.002928783,0.001304192,0.004719052,0.0001315099,0.0001041536,0.0009290635,0.01108408,0.0002315573,0.001342512,0.02054426],"study_design_scores_gemma":[0.7795398,0.1989991,0.01231519,0.00004956407,0.003654991,0.000151647,0.00004645026,0.001262187,0.001932851,0.0001610314,0.00183953,0.00004775197],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841222,0.004346307,0.001240709,0.0003662028,0.0001433004,0.005830897,0.001749544,0.000154627,0.002046275],"genre_scores_gemma":[0.9798175,0.003303582,0.003710383,0.0007624991,0.000373637,0.006268391,0.003414344,0.00004957443,0.002300075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004048354,"threshold_uncertainty_score":0.01543593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05820247976203907,"score_gpt":0.4253257084668676,"score_spread":0.3671232287048285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}