{"id":"W4367669706","doi":"10.1093/cercor/bhad137","title":"Altered structural covariance of locus coeruleus in individuals with significant memory concern and patients with mild cognitive impairment","year":2023,"lang":"en","type":"article","venue":"Cerebral Cortex","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; National Institute on Aging; Natural Science Foundation of Guangdong Province; Alzheimer's Association","keywords":"Locus coeruleus; Default mode network; Biomarker; Audiology; Neuroscience; Cognitive impairment; Psychology; Cognition; Voxel-based morphometry; Disease; Internal medicine; Medicine; Magnetic resonance imaging; Biology; Central nervous system; White matter; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001775221,0.0002394799,0.0002495818,0.001014659,0.0003050219,0.0003736282,0.0002200454,0.000311219,0.0008545642],"category_scores_gemma":[0.001087787,0.0001353488,0.0001559437,0.0004472877,0.0003083737,0.0002177565,0.0003470039,0.0002252924,0.00008626357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002774066,"about_ca_system_score_gemma":0.0001629465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01021158,"about_ca_topic_score_gemma":0.01618705,"domain_scores_codex":[0.9998735,0.0000144193,0.00001558169,0.00004603698,0.00002965029,0.00002067902],"domain_scores_gemma":[0.9995852,0.00005449264,0.0002149171,0.00003776755,0.00003971807,0.00006793597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002498558,0.00002899634,0.9941165,0.000007887056,0.0000770665,0.0003374866,0.000226118,0.00005799072,0.002703259,0.00003950869,0.0000305724,0.00212474],"study_design_scores_gemma":[0.000002867558,0.00003110781,0.999368,7.840904e-7,0.00001000789,0.0002986459,0.00005494843,0.00009283118,0.00008730726,0.00003292728,0.00001939759,0.000001184347],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997231,0.00006071496,0.00004374423,0.000006827678,8.368729e-7,0.000002443592,0.00003081594,0.000001535339,0.0001299367],"genre_scores_gemma":[0.9998701,0.00001368909,0.0000305848,0.000004122216,0.000001542357,8.97166e-7,0.00004042306,5.445293e-7,0.00003803107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01021158,"threshold_uncertainty_score":0.02030432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02281703452916492,"score_gpt":0.2896652063330507,"score_spread":0.2668481718038858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}