{"id":"W4367669706","doi":"10.1093/cercor/bhad137","title":"Altered structural covariance of locus coeruleus in individuals with significant memory concern and patients with mild cognitive impairment","year":2023,"lang":"en","type":"article","venue":"Cerebral Cortex","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; National Institute on Aging; Natural Science Foundation of Guangdong Province; Alzheimer's Association","keywords":"Locus coeruleus; Default mode network; Biomarker; Audiology; Neuroscience; Cognitive impairment; Psychology; Cognition; Voxel-based morphometry; Disease; Internal medicine; Medicine; Magnetic resonance imaging; Biology; Central nervous system; White matter; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008375705,0.0002135963,0.0003971077,0.0001505659,0.00005740434,0.0000172314,0.00006416306,0.00005560449,0.0001229785],"category_scores_gemma":[0.00002146155,0.0001403719,0.00003287845,0.0003822563,0.000326119,0.000110247,0.00005980252,0.0001643093,0.00001899128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005470697,"about_ca_system_score_gemma":0.0002708945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002652016,"about_ca_topic_score_gemma":0.00005371059,"domain_scores_codex":[0.9983246,0.00006241653,0.0002371245,0.0003734824,0.000588947,0.000413376],"domain_scores_gemma":[0.9991144,0.0000813392,0.0001218448,0.0001796967,0.0001992332,0.0003034907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002245235,0.0002222382,0.9937552,0.000105209,0.001887868,0.0001664529,0.0003782329,0.000003675583,0.00001494573,0.00001347304,0.000103358,0.001104139],"study_design_scores_gemma":[0.01590732,0.002466795,0.979535,0.0003778075,0.0003101125,0.000008198369,0.000628144,0.00009622177,0.0004592626,0.00005177089,0.000001692572,0.0001576076],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974262,0.0003713853,0.000002768772,0.00006785171,0.00002660564,0.001432395,0.0004708685,0.00003780904,0.0001641672],"genre_scores_gemma":[0.9991926,0.0000216688,0.00009371984,0.00006612806,0.00002389947,0.00006598327,0.0004724068,0.00002763037,0.00003597239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01422011,"threshold_uncertainty_score":0.5724202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02281703452916492,"score_gpt":0.2896652063330507,"score_spread":0.2668481718038858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}