{"id":"W4367677780","doi":"10.1016/j.ijrobp.2023.04.010","title":"Genomic Classifier Performance in Intermediate-Risk Prostate Cancer: Results From NRG Oncology/RTOG 0126 Randomized Phase 3 Trial","year":2023,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Prostate Cancer Diagnosis and Treatment","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; Hamilton Regional Laboratory Medicine Program; Université Laval; Princess Margaret Cancer Centre","funders":"Janssen Biotech; Astellas Pharma; Veracyte; NRG Oncology; National Cancer Institute; Foundation Medicine; Boston Scientific Corporation; Varian Medical Systems; AstraZeneca; Bristol-Myers Squibb","keywords":"Medicine; Prostate cancer; Internal medicine; Oncology; Hazard ratio; Clinical endpoint; Randomized controlled trial; Hormonal therapy; Cancer; Prostate; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002134319,0.001102479,0.001629294,0.0002487198,0.0002605866,0.001048143,0.0006076675,0.0009578723,0.002973935],"category_scores_gemma":[0.002862368,0.0002864698,0.001776957,0.00031157,0.0006773789,0.0008518797,0.0003312294,0.001892327,0.0006028202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006154475,"about_ca_system_score_gemma":0.0005839663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007602253,"about_ca_topic_score_gemma":0.00149984,"domain_scores_codex":[0.9991358,0.000508618,0.00002639419,0.0002033579,0.0000716896,0.00005412462],"domain_scores_gemma":[0.9988978,0.0005224618,0.0002266158,0.0001225918,0.00005933288,0.0001711954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7925362,0.005689602,0.02981546,0.001622335,0.009000897,0.0001079188,0.000160656,0.008509712,0.01061845,0.0005973486,0.01338799,0.1279535],"study_design_scores_gemma":[0.6739811,0.1493146,0.1114892,0.0006024137,0.01992396,0.0005901124,0.0002306786,0.01874037,0.006682353,0.006142604,0.01208426,0.0002183609],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843928,0.008236568,0.001096944,0.001548019,0.0002957847,0.0003659814,0.002032737,0.00015862,0.001872512],"genre_scores_gemma":[0.9877728,0.002168779,0.002212255,0.001291284,0.0002813457,0.0003832355,0.004245443,0.00005539961,0.001589504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002973935,"threshold_uncertainty_score":0.01128751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0317009965620627,"score_gpt":0.3633305761617859,"score_spread":0.3316295795997232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}