{"id":"W4367677781","doi":"10.7554/elife.86784.1","title":"Structural insight into guanylyl cyclase receptor hijacking of the kinase–Hsp90 regulatory mechanism","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; G. Harold and Leila Y. Mathers Foundation; Howard Hughes Medical Institute","keywords":"Hsp90; GUCY2D; Kinase; Cell biology; Druggability; CDC37; Chaperone (clinical); Biology; Receptor; Guanylate cyclase 2C; Chemistry; Protein kinase A; Biochemistry; Cyclase; Medicine; Heat shock protein; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008122454,0.0002461671,0.0002398682,0.0001059758,0.0002791156,0.0002853571,0.0003213296,0.0004698788,0.003017548],"category_scores_gemma":[0.00008284134,0.0001335203,0.0002103046,0.0001230494,0.0002925654,0.000349658,0.0002443001,0.0009744717,0.0006023966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004916068,"about_ca_system_score_gemma":0.0002598986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001845323,"about_ca_topic_score_gemma":0.001330657,"domain_scores_codex":[0.9999677,0.000003705743,0.000001005175,0.000006588768,0.00001038166,0.00001067155],"domain_scores_gemma":[0.9999667,0.000005969048,0.000008105381,0.000004185983,0.000004117078,0.00001083099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000247956,0.0000604645,0.001291607,0.0002231818,0.00003209466,0.001441206,0.0001265111,0.004747307,0.9794948,0.005453942,0.002493178,0.004387675],"study_design_scores_gemma":[0.0001870043,0.0004880316,0.03726595,0.0001292857,0.00009562985,0.004402285,0.0008695136,0.1111162,0.7606652,0.01594492,0.06873173,0.0001042185],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9714547,0.00602064,0.01201009,0.001989867,0.0001640025,0.00001915437,0.0006626489,0.0006080625,0.007070759],"genre_scores_gemma":[0.9928811,0.001582605,0.002978109,0.0002302389,0.00001993385,0.000005654053,0.0005952399,0.00003133739,0.00167589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003017548,"threshold_uncertainty_score":0.0100947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02838176198958574,"score_gpt":0.2960822596894541,"score_spread":0.2677004976998684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}