{"id":"W4367693499","doi":"10.1021/acsmaterialsau.3c00009","title":"Antisenescence Therapy Improves Function in a Human Model of Cardiac Fibrosis-on-a-Chip","year":2023,"lang":"en","type":"article","venue":"ACS Materials Au","topic":"Tissue Engineering and Regenerative Medicine","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Heart and Stroke Foundation; Toronto General Hospital; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; University of Toronto; Natural Sciences and Engineering Research Council of Canada; Toronto General Hospital Research Institute, University Health Network; Ontario Ministry of Research, Innovation and Science","keywords":"Cardiac fibrosis; Fibrosis; Senescence; Fibroblast; Myocardial fibrosis; Cardiac function curve; Cancer research; Heart failure; Dasatinib; Transcriptome; Medicine; Induced pluripotent stem cell; Biology; Bioinformatics; Cell biology; Pathology; Gene expression; Internal medicine; Gene; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003966898,0.0004255841,0.0003809987,0.0002444882,0.0001497837,0.000228583,0.000264667,0.0004355859,0.001721362],"category_scores_gemma":[0.0001527453,0.000145501,0.0003259708,0.0001029748,0.0002429095,0.0001634943,0.0001767812,0.000731882,0.00037894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001198158,"about_ca_system_score_gemma":0.0001544096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004438095,"about_ca_topic_score_gemma":0.0009355382,"domain_scores_codex":[0.9997373,0.00004012742,0.00001443516,0.00006791425,0.00008783778,0.000052315],"domain_scores_gemma":[0.9998692,0.0000307501,0.00002723319,0.00002197778,0.00001936319,0.00003150383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001236986,0.00009714376,0.00007648243,0.0000407734,0.000009243503,0.00002991929,0.00001246622,0.0001038415,0.9967337,0.00005830158,0.0001721021,0.002542414],"study_design_scores_gemma":[0.00002906728,0.001279276,0.003016612,0.0000075691,0.00003059615,0.0002206651,0.00002392602,0.002088197,0.9902015,0.00005000921,0.003044716,0.000007856896],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9669856,0.002846451,0.02384129,0.0003439167,0.0002705711,0.0001260187,0.0008145719,0.0005814907,0.004190099],"genre_scores_gemma":[0.9790443,0.001148156,0.01406871,0.0002409646,0.00002553037,0.0001425871,0.0008165224,0.00007556727,0.004437722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001721362,"threshold_uncertainty_score":0.005758524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03244419766234071,"score_gpt":0.2831049489758604,"score_spread":0.2506607513135197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}