{"id":"W4367693499","doi":"10.1021/acsmaterialsau.3c00009","title":"Antisenescence Therapy Improves Function in a Human Model of Cardiac Fibrosis-on-a-Chip","year":2023,"lang":"en","type":"article","venue":"ACS Materials Au","topic":"Tissue Engineering and Regenerative Medicine","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Heart and Stroke Foundation; Toronto General Hospital; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; University of Toronto; Natural Sciences and Engineering Research Council of Canada; Toronto General Hospital Research Institute, University Health Network; Ontario Ministry of Research, Innovation and Science","keywords":"Cardiac fibrosis; Fibrosis; Senescence; Fibroblast; Myocardial fibrosis; Cardiac function curve; Cancer research; Heart failure; Dasatinib; Transcriptome; Medicine; Induced pluripotent stem cell; Biology; Bioinformatics; Cell biology; Pathology; Gene expression; Internal medicine; Gene; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002484954,0.0001195325,0.0003489026,0.0001475413,0.00003206315,0.000005984055,0.00004258564,0.00006474207,0.00001393209],"category_scores_gemma":[0.00003105247,0.00008746115,0.00003338887,0.0001851443,0.0000444816,0.00002815059,0.00001523673,0.00005605239,0.00001215212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002747213,"about_ca_system_score_gemma":0.00003524201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001151543,"about_ca_topic_score_gemma":0.000001604872,"domain_scores_codex":[0.9992443,0.0000316864,0.0002236908,0.0001690153,0.0001517471,0.0001796124],"domain_scores_gemma":[0.9996564,0.0000212301,0.0000491894,0.0002021923,0.00002860406,0.00004239066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001076704,0.00003560734,0.0008014416,0.0001157684,0.00002276904,0.000002896229,0.0003348172,0.0005794251,0.9961098,0.0003943882,0.000369392,0.001126033],"study_design_scores_gemma":[0.0006489782,0.0004686413,0.08046667,0.0002160724,0.00001438566,8.802768e-7,0.00004264254,0.0002627669,0.9175408,0.00006121987,0.0001966402,0.00008030447],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983312,0.0003156748,0.00005287236,0.0002015492,0.000695047,0.0002486212,0.0000193465,0.00008434705,0.00005127298],"genre_scores_gemma":[0.997731,0.0001957617,0.000064552,0.00002214089,0.0003558614,0.00002968356,0.00005563333,0.0000243737,0.001520995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07966522,"threshold_uncertainty_score":0.3566562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03244419766234071,"score_gpt":0.2831049489758604,"score_spread":0.2506607513135197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}