{"id":"W4367693965","doi":"10.1016/j.jaccao.2023.02.004","title":"Endothelin Receptor Blocker Reverses Breast Cancer–Induced Cardiac Remodeling","year":2023,"lang":"en","type":"article","venue":"JACC CardioOncology","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Alberta Cancer Foundation; University of Alberta","funders":"University of Alberta; Canadian Institutes of Health Research; Women and Children's Health Research Institute; Children's Health Research Institute","keywords":"Breast cancer; Medicine; Internal medicine; Cardiac function curve; Endothelin receptor; Ventricular remodeling; Cancer; Oncology; Heart failure; Ejection fraction; Cardiology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006742704,0.0002886669,0.0009483791,0.0002762676,0.0001659366,0.00002183777,0.0001284602,0.0004621426,0.0002510865],"category_scores_gemma":[0.0001290654,0.0002843642,0.000624302,0.0006903969,0.00008185965,0.0001072523,0.00007707994,0.0004701383,0.0004775974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005542673,"about_ca_system_score_gemma":0.0004560862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002806608,"about_ca_topic_score_gemma":0.00001922638,"domain_scores_codex":[0.9978195,0.0002038227,0.0003739195,0.000593308,0.0004056475,0.0006037467],"domain_scores_gemma":[0.9986452,0.0001775657,0.0001250936,0.0005446828,0.0002701022,0.0002373904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003301797,0.0000355181,0.003315413,0.00007035024,0.0005379761,0.00005636561,0.0004266507,0.0001284977,0.9149954,0.00008034441,0.02402015,0.05600317],"study_design_scores_gemma":[0.006505857,0.0004235934,0.02917885,0.0003506319,0.0009841037,0.0008213636,0.002129237,0.001030295,0.5763287,0.0001624571,0.3810814,0.001003494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808981,0.0002824758,0.00006031954,0.008696352,0.002545227,0.0008217997,0.0002400699,0.0005584965,0.005897184],"genre_scores_gemma":[0.9898908,0.001535442,0.0004429604,0.001481134,0.003388307,0.000217378,0.0001245351,0.00008959336,0.002829873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3570613,"threshold_uncertainty_score":0.9999608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03349154012934019,"score_gpt":0.309296018367255,"score_spread":0.2758044782379148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}