{"id":"W4367693965","doi":"10.1016/j.jaccao.2023.02.004","title":"Endothelin Receptor Blocker Reverses Breast Cancer–Induced Cardiac Remodeling","year":2023,"lang":"en","type":"article","venue":"JACC CardioOncology","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Alberta Cancer Foundation; University of Alberta","funders":"University of Alberta; Canadian Institutes of Health Research; Women and Children's Health Research Institute; Children's Health Research Institute","keywords":"Breast cancer; Medicine; Internal medicine; Cardiac function curve; Endothelin receptor; Ventricular remodeling; Cancer; Oncology; Heart failure; Ejection fraction; Cardiology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001360847,0.000176434,0.0003124305,0.0001433827,0.00007786287,0.0001206228,0.0001449353,0.0001765728,0.001394475],"category_scores_gemma":[0.000135516,0.00006915223,0.0001927719,0.00007797506,0.0000964901,0.00009756699,0.0000915881,0.0005587006,0.0002579218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007383357,"about_ca_system_score_gemma":0.0001243475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001182839,"about_ca_topic_score_gemma":0.0002949627,"domain_scores_codex":[0.9999508,0.00001183637,0.000004475791,0.000007351901,0.00001232704,0.00001319967],"domain_scores_gemma":[0.9999347,0.0000117144,0.00002455441,0.000006772399,0.000007528896,0.00001479645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004024012,0.001679837,0.002877046,0.0002656597,0.00008847292,0.0002129055,0.00003973282,0.0002234171,0.9476521,0.0001113773,0.0004399598,0.04238543],"study_design_scores_gemma":[0.002023804,0.06424113,0.07996265,0.00006655836,0.0004529758,0.002761409,0.0001535308,0.002603007,0.8318449,0.0002143578,0.01565332,0.00002228059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927912,0.004998815,0.0006829143,0.000166734,0.00009702851,0.00004890831,0.00007874307,0.00008102507,0.00105462],"genre_scores_gemma":[0.9931303,0.003426639,0.0009562044,0.0002105667,0.00007444892,0.00004164716,0.0001975405,0.00001439727,0.00194822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001394475,"threshold_uncertainty_score":0.004665017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03349154012934019,"score_gpt":0.309296018367255,"score_spread":0.2758044782379148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}