{"id":"W4367834178","doi":"10.4049/jimmunol.2300103","title":"Extracellular RNA Sensing Mediates Inflammation and Organ Injury in a Murine Model of Polytrauma","year":2023,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; U.S. Air Force; Air Force Research Laboratory; National Institutes of Health; Dalhousie University","keywords":"Proinflammatory cytokine; Polytrauma; Inflammation; Cytokine; TLR7; Biology; Immunology; Medicine; Innate immune system; Immune system; Toll-like receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002741111,0.001026666,0.0004730102,0.0007726265,0.0002576181,0.0003885851,0.0002506495,0.0006092963,0.001379261],"category_scores_gemma":[0.0001293288,0.0002583343,0.0005256177,0.0003170399,0.0004431118,0.000341305,0.0003348246,0.001429726,0.0004134625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002456356,"about_ca_system_score_gemma":0.0002332655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001735484,"about_ca_topic_score_gemma":0.0003424304,"domain_scores_codex":[0.9995995,0.00008038029,0.00003709323,0.0001064986,0.00009752021,0.0000790638],"domain_scores_gemma":[0.9998134,0.00001318649,0.00007241762,0.00002620802,0.00001682682,0.00005795808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003788092,0.00008783911,0.0002276642,0.00005606609,0.000009946002,0.00008369861,0.00001855296,0.00004924485,0.9980767,0.00006031776,0.00002764919,0.0009233794],"study_design_scores_gemma":[0.00009253523,0.004040759,0.01515452,0.00004090334,0.00008722293,0.001101795,0.00009563271,0.001869745,0.9741881,0.0002006658,0.003109814,0.00001830756],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884311,0.002459172,0.006239779,0.0002296453,0.00009966431,0.0001531629,0.0008351518,0.0001633638,0.001388953],"genre_scores_gemma":[0.9853436,0.002571952,0.006639471,0.0002043738,0.00004621154,0.0003707365,0.001302358,0.00003760334,0.003483799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001379261,"threshold_uncertainty_score":0.004614055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01200692047673948,"score_gpt":0.258883856539048,"score_spread":0.2468769360623085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}