{"id":"W4367834706","doi":"10.1080/19490976.2023.2205425","title":"Crohn’s disease proteolytic microbiota enhances inflammation through PAR2 pathway in gnotobiotic mice","year":2023,"lang":"en","type":"article","venue":"Gut Microbes","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; McMaster University; Population Health Research Institute","funders":"Canadian Institutes of Health Research; Weston Family Foundation; Deutsche Forschungsgemeinschaft; McMaster University","keywords":"Biology; Colitis; Proteases; Proteolytic enzymes; Inflammation; Immunology; NOD2; Proinflammatory cytokine; Microbiology; Immune system; Innate immune system; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002120148,0.0002847695,0.0001786652,0.0001129176,0.0001132632,0.00006977634,0.0003213692,0.0001643228,0.00004136849],"category_scores_gemma":[0.0001694131,0.0002925756,0.0001316451,0.0002695417,0.0001351368,0.00002922876,0.0001952741,0.0001204835,0.000577885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004675665,"about_ca_system_score_gemma":0.0002492745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003570875,"about_ca_topic_score_gemma":0.0002290226,"domain_scores_codex":[0.9982696,0.0001251718,0.0003969111,0.0005711295,0.0001244701,0.0005127414],"domain_scores_gemma":[0.9991684,0.00001594556,0.0001227191,0.0004933251,0.00007752551,0.0001220843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000227549,0.00005650195,0.003346259,0.0002160404,0.00002549883,0.0004481064,0.0002284135,0.0001828965,0.9929807,0.0001003941,0.001819995,0.0003676537],"study_design_scores_gemma":[0.0009081553,0.00003278175,0.2909493,0.0001563948,0.00002107471,0.000007044339,0.0001327375,0.00008583175,0.6921796,0.0003150901,0.01470046,0.0005115182],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976721,0.000397034,0.00008152706,0.0002621293,0.0002244141,0.0008853677,0.00010108,0.0000839309,0.0002924592],"genre_scores_gemma":[0.9968961,0.0001403274,0.0002493123,0.0002222218,0.0002717417,0.0001715908,0.0005046365,0.00004871414,0.001495285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3008011,"threshold_uncertainty_score":0.9999526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008784165331549455,"score_gpt":0.2356588135754637,"score_spread":0.2268746482439142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}