{"id":"W4367835343","doi":"10.1111/acel.13842","title":"Nanopore sequencing identifies a higher frequency and expanded spectrum of mitochondrial <scp>DNA</scp> deletion mutations in human aging","year":2023,"lang":"en","type":"article","venue":"Aging Cell","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Oxford Nanopore Technologies; National Institute on Aging; National Institutes of Health; Dermatology Foundation","keywords":"Mitochondrial DNA; Biology; Genetics; Mutation frequency; Mutation; Breakpoint; DNA sequencing; Gene; Chromosomal translocation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002751731,0.0001884176,0.0002472572,0.0004549092,0.0001768171,0.0002258104,0.0001721623,0.0004141447,0.0005153726],"category_scores_gemma":[0.0005076721,0.0001429672,0.0001666906,0.0001631318,0.0002115404,0.0001964936,0.0002310625,0.0001897824,0.0001447271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001626115,"about_ca_system_score_gemma":0.00009673461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001525438,"about_ca_topic_score_gemma":0.003317833,"domain_scores_codex":[0.9998294,0.00001541481,0.00001265976,0.00007382571,0.00005143157,0.00001716074],"domain_scores_gemma":[0.9996673,0.0001009181,0.00009036675,0.00003811266,0.00006701304,0.00003639594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001157509,0.00001941705,0.0302124,0.00003138764,0.00002971144,0.0001544491,0.00008896637,0.000427791,0.9635196,0.00005114349,0.00004942519,0.005299789],"study_design_scores_gemma":[0.000009918521,0.0004314352,0.5160909,0.00001825792,0.00009862121,0.002708131,0.000180395,0.009477481,0.4689007,0.0002745386,0.001780199,0.00002940566],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941769,0.0003480529,0.004970514,0.00002238454,0.000003458701,0.000005608611,0.0001990699,0.00007172288,0.0002022914],"genre_scores_gemma":[0.9919842,0.0001777157,0.007017402,0.00004128836,0.000003687991,0.00001478528,0.0003503436,0.00001504506,0.0003956022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001525438,"threshold_uncertainty_score":0.003033161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0152046948749889,"score_gpt":0.2545280048649087,"score_spread":0.2393233099899198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}