{"id":"W4367835344","doi":"10.1080/22221751.2023.2210237","title":"Impaired potency of neutralizing antibodies against cell–cell fusion mediated by SARS-CoV-2","year":2023,"lang":"en","type":"article","venue":"Emerging Microbes & Infections","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Columbia College","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Virology; Monoclonal antibody; Cell fusion; Antibody; Cell; Biology; Virus; Cell culture; Viral entry; Neutralizing antibody; Potency; Immunology; In vitro; Viral replication; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004314478,0.000663262,0.0004897929,0.0002886805,0.000122005,0.0004290266,0.0003560256,0.0004294147,0.001142645],"category_scores_gemma":[0.0004577401,0.0001827888,0.0003481243,0.0001800151,0.0001745821,0.0002563489,0.0003100756,0.0007862935,0.000373227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002997355,"about_ca_system_score_gemma":0.0002159041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001053145,"about_ca_topic_score_gemma":0.0006976553,"domain_scores_codex":[0.999408,0.0001637489,0.00005081773,0.00006347705,0.0001939227,0.0001199722],"domain_scores_gemma":[0.9996997,0.0001081983,0.00004417412,0.00004824025,0.00006967947,0.00002993758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001039401,0.00008083228,0.0003379327,0.00002785782,0.00001322173,0.00001134158,0.00001704767,0.0001739925,0.99751,0.00004151163,0.00005771618,0.001624612],"study_design_scores_gemma":[0.00001963124,0.001246967,0.004385038,0.000005834793,0.00001934363,0.0001784996,0.00001826043,0.001522243,0.9915958,0.00003731674,0.0009648403,0.00000615632],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936652,0.001353183,0.002840295,0.00005861595,0.00004345002,0.00003848585,0.000367993,0.00007164545,0.001561059],"genre_scores_gemma":[0.9966588,0.0003187218,0.001176757,0.00005148474,0.00001121056,0.00002128267,0.0007775851,0.00001183632,0.0009723921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001142645,"threshold_uncertainty_score":0.003822565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02756972519084683,"score_gpt":0.3245516861033593,"score_spread":0.2969819609125124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}