{"id":"W4367835344","doi":"10.1080/22221751.2023.2210237","title":"Impaired potency of neutralizing antibodies against cell–cell fusion mediated by SARS-CoV-2","year":2023,"lang":"en","type":"article","venue":"Emerging Microbes & Infections","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Columbia College","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Virology; Monoclonal antibody; Cell fusion; Antibody; Cell; Biology; Virus; Cell culture; Viral entry; Neutralizing antibody; Potency; Immunology; In vitro; Viral replication; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003850661,0.0002942354,0.0004466954,0.0008112862,0.0003682045,0.00003802844,0.0001794335,0.0001821715,0.00002174438],"category_scores_gemma":[0.0001513652,0.0002846227,0.000297467,0.001851425,0.0001624259,0.0001578939,0.0001795833,0.0004346661,0.0004040774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001115013,"about_ca_system_score_gemma":0.0002039264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002190762,"about_ca_topic_score_gemma":0.0001833786,"domain_scores_codex":[0.9978937,0.0001005496,0.0005459082,0.0004461161,0.0003429083,0.0006708344],"domain_scores_gemma":[0.9989268,0.0001790876,0.0001547299,0.0004397206,0.0002481836,0.00005148576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002841927,0.0004069976,0.04596533,0.0003047564,0.00006154701,0.00003235385,0.0008337301,0.000008807912,0.922523,0.000007289814,0.02914557,0.0006822258],"study_design_scores_gemma":[0.001123123,0.0001854124,0.003384813,0.000175387,0.00007482085,0.00001615045,0.0003525081,0.0004094838,0.8975844,0.00002193385,0.09642835,0.000243607],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905539,0.0009441637,0.0001244449,0.0004888119,0.0004408748,0.00043229,0.00005953244,0.0005439165,0.006412119],"genre_scores_gemma":[0.9954484,0.0004192973,0.00009463183,0.003340041,0.0001277992,0.00002869226,0.0001213883,0.00007607118,0.000343673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06728278,"threshold_uncertainty_score":0.9999606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02756972519084683,"score_gpt":0.3245516861033593,"score_spread":0.2969819609125124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}