{"id":"W4367837632","doi":"10.1093/cei/uxad049","title":"Destined for the intestine: thymic selection of TCR<b>αβ</b> CD8αα intestinal intraepithelial lymphocytes","year":2023,"lang":"en","type":"review","venue":"Clinical & Experimental Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Faculty of Medicine and Dentistry, University of Alberta; Canadian Institutes of Health Research; University of Alberta","keywords":"Intraepithelial lymphocyte; Biology; Immunology; T-cell receptor; CD8; Intestinal epithelium; Immune system; Epithelium; Cytotoxic T cell; T cell; Cell biology; Homeostasis; Lymphopoiesis; Lymphatic system; Haematopoiesis; Stem cell; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004332929,0.0005277668,0.0007721323,0.0009197933,0.0001837518,0.000828542,0.0005568362,0.0009212418,0.00187719],"category_scores_gemma":[0.0005154106,0.0001767435,0.0002212562,0.0008252292,0.0003977432,0.001037666,0.0004947607,0.001756144,0.001974941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005132038,"about_ca_system_score_gemma":0.0007130132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004836075,"about_ca_topic_score_gemma":0.0007019195,"domain_scores_codex":[0.9998868,0.00001816055,0.00001591587,0.00002661566,0.00003944588,0.00001300936],"domain_scores_gemma":[0.999826,0.00007274324,0.00002310465,0.000005570218,0.00004734351,0.00002522878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001012533,0.00003411038,0.0002585341,0.01034838,0.00004306396,0.0003033425,0.00008156413,0.0002152448,0.00407972,0.005228236,0.03349587,0.9458107],"study_design_scores_gemma":[0.0000117485,0.00006766663,0.0009474502,0.001802836,0.00004377248,0.001458197,0.00005271532,0.00003699299,0.0007728211,0.001482888,0.993313,0.00001003706],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001576535,0.9982336,0.0001033914,0.0003370026,0.0003673478,0.000002567971,0.00001073013,0.000005803221,0.0007817908],"genre_scores_gemma":[0.0007260061,0.9979393,0.0001085536,0.0002629605,0.0002758075,0.000004667476,0.00002293923,0.000001871055,0.000657948],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00187719,"threshold_uncertainty_score":0.006279826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1243684500092137,"score_gpt":0.4256554413204862,"score_spread":0.3012869913112725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}