{"id":"W4367837632","doi":"10.1093/cei/uxad049","title":"Destined for the intestine: thymic selection of TCR<b>αβ</b> CD8αα intestinal intraepithelial lymphocytes","year":2023,"lang":"en","type":"review","venue":"Clinical & Experimental Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Faculty of Medicine and Dentistry, University of Alberta; Canadian Institutes of Health Research; University of Alberta","keywords":"Intraepithelial lymphocyte; Biology; Immunology; T-cell receptor; CD8; Intestinal epithelium; Immune system; Epithelium; Cytotoxic T cell; T cell; Cell biology; Homeostasis; Lymphopoiesis; Lymphatic system; Haematopoiesis; Stem cell; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001083572,0.0007356373,0.002403282,0.0003103705,0.0004135367,0.00003346218,0.0009252885,0.001309551,0.001373699],"category_scores_gemma":[0.003067212,0.0005153354,0.001512373,0.0004858547,0.001401022,0.0001113951,0.0004419739,0.001516668,0.001929516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002549429,"about_ca_system_score_gemma":0.0005218075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001389622,"about_ca_topic_score_gemma":0.000008920423,"domain_scores_codex":[0.9944621,0.001094315,0.002829995,0.0008648087,0.00006682429,0.0006819562],"domain_scores_gemma":[0.9892735,0.008119007,0.001630413,0.0006570158,0.0002846989,0.00003532653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002949977,0.001812175,0.0000572302,0.001975258,0.005217037,0.000007074598,0.0002307212,0.000002562764,0.0427761,0.001301797,0.04020822,0.9034618],"study_design_scores_gemma":[0.002369489,0.003178479,0.00004397369,0.002924583,0.001120401,0.0007191931,0.0005387836,0.0000297828,0.01733082,0.00003942714,0.9711419,0.0005631216],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000663075,0.9777834,0.0004290085,0.00006093313,0.01860474,0.001838189,0.00003491226,0.0003350318,0.0002507064],"genre_scores_gemma":[0.001644902,0.9882486,0.0002336028,0.0001276524,0.000517272,0.001091806,0.0006889995,0.0001776177,0.007269589],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9309337,"threshold_uncertainty_score":0.9999869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1243684500092137,"score_gpt":0.4256554413204862,"score_spread":0.3012869913112725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}