{"id":"W4367840089","doi":"10.1158/1078-0432.ccr-23-0252","title":"Intravenous N-Acetylcysteine to Prevent Cisplatin-Induced Hearing Loss in Children: A Nonrandomized Controlled Phase I Trial","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Hearing, Cochlea, Tinnitus, Genetics","field":"Neuroscience","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Center for Advancing Translational Sciences; National Institute on Deafness and Other Communication Disorders; National Cancer Institute; National Institutes of Health; American Cancer Society","keywords":"Medicine; Acetylcysteine; Cisplatin; Adverse effect; Ototoxicity; Confidence interval; Internal medicine; Surgery; Chemotherapy; Antioxidant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001590419,0.001019653,0.002008009,0.0002974325,0.0003074035,0.000654435,0.0007154653,0.0009561626,0.002009353],"category_scores_gemma":[0.001590057,0.0004007586,0.001137692,0.0003851477,0.001035792,0.0005985706,0.0002533189,0.002323092,0.0003337268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009251253,"about_ca_system_score_gemma":0.002003958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008152529,"about_ca_topic_score_gemma":0.001943395,"domain_scores_codex":[0.9993266,0.0003836769,0.00004868164,0.00009974278,0.00006997512,0.00007131906],"domain_scores_gemma":[0.9988587,0.0002752411,0.0003585928,0.0001113073,0.00009041128,0.0003057352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8974913,0.02514209,0.006716263,0.001322787,0.001976314,0.0001904606,0.0001663134,0.00107697,0.01391335,0.0002364754,0.001516872,0.05025089],"study_design_scores_gemma":[0.7021806,0.2873862,0.005443559,0.00007167225,0.0005841181,0.0001738973,0.00003271021,0.0004856203,0.002031311,0.0001012164,0.0014946,0.00001439948],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897344,0.003906347,0.0008153259,0.0003393618,0.0001285891,0.00366466,0.0006036687,0.00007873245,0.0007287636],"genre_scores_gemma":[0.9874023,0.003422082,0.002217638,0.000722551,0.0001672156,0.004377417,0.0007044148,0.00002458086,0.0009617775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002009353,"threshold_uncertainty_score":0.00841105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3383810776774833,"score_gpt":0.5554029596086443,"score_spread":0.217021881931161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}