{"id":"W4367845438","doi":"10.1101/2023.04.29.23289260","title":"Efficacy of N-163 strain of <i>Aureobasidium pullulans</i> -produced beta-glucan in improving muscle strength and function in patients with Duchenne muscular dystrophy; Results of a 6-month non-randomised open-label linear clinical trial","year":2023,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thunder Bay Regional Health Sciences Centre","funders":"","keywords":"Duchenne muscular dystrophy; Ambulatory; Medicine; Aureobasidium pullulans; Regimen; Clinical trial; Muscular dystrophy; Internal medicine; Strain (injury); Adjuvant; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001292128,0.0008441954,0.00160706,0.000307243,0.0003873539,0.0004529814,0.0005608056,0.001145931,0.002303612],"category_scores_gemma":[0.0005620302,0.0002784039,0.0009548804,0.0002280844,0.0006163821,0.000548669,0.0002768341,0.001445897,0.0004943801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003456794,"about_ca_system_score_gemma":0.000404228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005082939,"about_ca_topic_score_gemma":0.0009355413,"domain_scores_codex":[0.9996083,0.0001885427,0.00003684827,0.00006550378,0.00003882829,0.00006201453],"domain_scores_gemma":[0.9993895,0.0001126624,0.0001300111,0.00004343657,0.00005547828,0.0002688806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8599731,0.05172728,0.002490398,0.000694485,0.0006473532,0.0001314733,0.0000845622,0.0003577248,0.03773998,0.00004954155,0.0004941486,0.04560984],"study_design_scores_gemma":[0.2364473,0.7479926,0.01133518,0.00003701172,0.0002409001,0.00008364408,0.00004104034,0.0003743259,0.00295027,0.00003218054,0.000446822,0.00001874811],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969577,0.001429774,0.0001930589,0.000117393,0.0000546666,0.000525691,0.0002153876,0.0000359532,0.0004703517],"genre_scores_gemma":[0.9962823,0.0009144278,0.000652464,0.0002347404,0.0001169593,0.0005428723,0.0003984144,0.000008285119,0.0008495925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002303612,"threshold_uncertainty_score":0.007706285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03405612708980371,"score_gpt":0.3000770486005527,"score_spread":0.266020921510749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}