{"id":"W4368347467","doi":"10.1126/science.adh7699","title":"Discovery of target genes and pathways at GWAS loci by pooled single-cell CRISPR screens","year":2023,"lang":"en","type":"article","venue":"Science","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":203,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Human Genome Research Institute; Canadian Institutes of Health Research; York University; National Institute of General Medical Sciences; National Institute of Mental Health; American Heart Association; National Cancer Institute; National Institutes of Health; National Science Foundation","keywords":"Biology; Genome-wide association study; Genetics; Gene; Computational biology; Genome; CRISPR; Genomics; Quantitative trait locus; Expression quantitative trait loci; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002346487,0.0001110048,0.0001151171,0.00005059743,0.0001541677,0.00003875849,0.0002506889,0.00006603896,0.000004035298],"category_scores_gemma":[0.00004437177,0.00009950285,0.00004553131,0.0002755067,0.0005484577,0.00001369572,0.0001795176,0.00003811374,0.000006049995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001271389,"about_ca_system_score_gemma":0.00007283504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003435133,"about_ca_topic_score_gemma":0.00002156993,"domain_scores_codex":[0.9989663,0.00001831813,0.0001476022,0.0003808079,0.0002021849,0.0002848112],"domain_scores_gemma":[0.9995622,0.00001128193,0.00005487209,0.0002347209,0.00006032069,0.00007659777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002232661,0.00004273222,0.005055903,0.00001777914,0.000003997746,0.000001532521,0.00006098847,0.00002863697,0.993182,0.00001472397,0.001035483,0.00053388],"study_design_scores_gemma":[0.0002475556,0.000187201,0.001387462,0.000006161483,0.000007073378,0.000002565469,0.00008080752,0.0002728624,0.9932548,0.0000598719,0.004360378,0.0001332464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963139,0.001344865,0.001276681,0.00006609136,0.0001395015,0.00008161864,0.00009249632,0.0000157529,0.0006691322],"genre_scores_gemma":[0.9977846,0.0002735176,0.0004508329,0.0001134119,0.00004533133,0.000002851137,0.00006620061,0.00001152754,0.001251731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003668441,"threshold_uncertainty_score":0.4057609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01645196169677083,"score_gpt":0.2235507517951499,"score_spread":0.207098790098379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}