{"id":"W4368353878","doi":"10.1016/j.psc.2023.02.001","title":"The Individual and Societal Burden of Treatment-Resistant Depression","year":2023,"lang":"en","type":"review","venue":"Psychiatric Clinics of North America","topic":"Treatment of Major Depression","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Mental Health; Otsuka Canada Pharmaceutical; Otsuka Pharmaceutical; Biogen; Sage Therapeutics; Neurocrine Biosciences; Takeda Pharmaceuticals U.S.A.","keywords":"Anhedonia; Depression (economics); Neurocognitive; Treatment-resistant depression; Antidepressant; Psychiatry; Major depressive disorder; Mood; Burden of disease; Psychology; Social functioning; Disease burden; Medicine; Clinical psychology; Disease; Cognition; Internal medicine; Anxiety; Schizophrenia (object-oriented programming)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002559551,0.0005319238,0.002468784,0.0002532492,0.0001696591,0.00001693658,0.000349987,0.0002686802,0.00001083808],"category_scores_gemma":[0.0002499828,0.0002922306,0.00112455,0.0008498121,0.0003539193,0.0000321979,0.0002231495,0.0003679992,0.00002744576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001035307,"about_ca_system_score_gemma":0.0006882554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001735258,"about_ca_topic_score_gemma":0.00002653668,"domain_scores_codex":[0.9966491,0.0001834267,0.001620569,0.0006056051,0.0005869303,0.0003543296],"domain_scores_gemma":[0.9947351,0.001962946,0.00206132,0.0009461523,0.000093533,0.0002009727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001394804,0.0002768881,0.005216674,0.004423344,0.001354429,0.000009269983,0.00008615978,0.000001116457,6.164921e-8,0.000002616296,0.0009660169,0.987524],"study_design_scores_gemma":[0.001763849,0.002345228,0.00487241,0.003380267,0.01009118,0.0000225637,0.00008609371,0.00001366519,1.302399e-7,0.00002987631,0.9771279,0.0002668998],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003450023,0.9939025,0.000003721525,0.00009186038,0.0004239583,0.001413996,0.0004965115,0.00006654568,0.0001508936],"genre_scores_gemma":[0.0003268135,0.9973473,0.0009492922,0.00001078919,0.0003228885,0.0001031542,0.0004188358,0.00009740036,0.0004235099],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9872571,"threshold_uncertainty_score":0.999953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07519593219416117,"score_gpt":0.3888916533026696,"score_spread":0.3136957211085085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}