{"id":"W4368356880","doi":"10.1093/eurheartj/ehad236","title":"Pre-treatment bicarbonate levels and decongestion by acetazolamide: the ADVOR trial","year":2023,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Relypsa; National Institutes of Health; Servier; Biosense Webster; Belgian Health Care Knowledge Centre; Novo Nordisk; Universität Zürich; Fonds Wetenschappelijk Onderzoek; Hamilton Health Sciences; Mundipharma Medical Company, Basel; European Commission; Inselspital, Universitätsspital Bern; Boston Scientific Corporation; Cardinal Health; Amgen; Edwards Lifesciences; Kiniksa Pharmaceuticals; Brigham and Women's Hospital; Sanofi; Vifor Pharma; Pfizer; ZOLL Medical Corporation; AstraZeneca; Belgian American Educational Foundation","keywords":"Acetazolamide; Medicine; Clinical endpoint; Diuretic; Placebo; Bicarbonate; Randomized controlled trial; Randomization; Sodium bicarbonate; Anesthesia; Internal medicine; Urology; Chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00316551,0.001314961,0.002790599,0.0002340713,0.0002821363,0.001250052,0.0008154421,0.001509412,0.004274479],"category_scores_gemma":[0.003311875,0.0003609782,0.002567719,0.0002557525,0.0009190658,0.0008814386,0.000522193,0.002586982,0.0005169217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005887656,"about_ca_system_score_gemma":0.0007907682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005515008,"about_ca_topic_score_gemma":0.001060674,"domain_scores_codex":[0.9982429,0.001158626,0.0001425638,0.0001628695,0.0001138938,0.0001792084],"domain_scores_gemma":[0.9980432,0.0007970231,0.000514107,0.000187517,0.0001208603,0.0003372641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.983136,0.001706499,0.001143037,0.0009076206,0.001449355,0.00002027717,0.00002832349,0.0001517952,0.001096833,0.00009150681,0.0003934777,0.009875222],"study_design_scores_gemma":[0.9384047,0.05303426,0.00451507,0.0001212438,0.001911642,0.00004767236,0.00003214127,0.0002675112,0.0005787667,0.0001732854,0.00089307,0.0000205824],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784073,0.01565902,0.0004000233,0.001361129,0.000542715,0.0008653785,0.0008097442,0.00006707757,0.001887668],"genre_scores_gemma":[0.9894724,0.004421983,0.0007980255,0.0009877164,0.0006962129,0.0009401819,0.0008875491,0.00001710115,0.00177887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004274479,"threshold_uncertainty_score":0.01674104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06407782425752495,"score_gpt":0.3316305130257619,"score_spread":0.267552688768237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}