{"id":"W4368356880","doi":"10.1093/eurheartj/ehad236","title":"Pre-treatment bicarbonate levels and decongestion by acetazolamide: the ADVOR trial","year":2023,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Relypsa; National Institutes of Health; Servier; Biosense Webster; Belgian Health Care Knowledge Centre; Novo Nordisk; Universität Zürich; Fonds Wetenschappelijk Onderzoek; Hamilton Health Sciences; Mundipharma Medical Company, Basel; European Commission; Inselspital, Universitätsspital Bern; Boston Scientific Corporation; Cardinal Health; Amgen; Edwards Lifesciences; Kiniksa Pharmaceuticals; Brigham and Women's Hospital; Sanofi; Vifor Pharma; Pfizer; ZOLL Medical Corporation; AstraZeneca; Belgian American Educational Foundation","keywords":"Acetazolamide; Medicine; Clinical endpoint; Diuretic; Placebo; Bicarbonate; Randomized controlled trial; Randomization; Sodium bicarbonate; Anesthesia; Internal medicine; Urology; Chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009158443,0.0001668645,0.0002155892,0.0001052131,0.0002860505,0.0001087302,0.00005683213,0.00002554727,0.0001267456],"category_scores_gemma":[0.0000727494,0.00009430262,0.0001119664,0.0001631669,0.00005539577,0.00008516946,0.00005610955,0.0001937316,0.0003716289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007350713,"about_ca_system_score_gemma":0.00004603047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007170509,"about_ca_topic_score_gemma":0.000003366844,"domain_scores_codex":[0.99869,0.0003105949,0.0002507158,0.0001987299,0.0002525163,0.0002974262],"domain_scores_gemma":[0.9993762,0.0001021325,0.00006447236,0.0002097793,0.00003262104,0.0002148348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.008976424,0.0007220551,0.0390427,0.00005046784,0.001186062,0.001786149,0.002142195,0.00002947929,0.008390382,0.0001636831,0.7671068,0.1704036],"study_design_scores_gemma":[0.02260538,0.001802278,0.2289161,0.00006135571,0.0002145127,0.0004913145,0.00009524373,0.0001195065,0.0002377227,0.0000316042,0.7453088,0.0001162969],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9594665,0.0005748172,0.00002573163,0.03636324,0.0004007799,0.0007680058,0.00000568072,0.0001261148,0.00226918],"genre_scores_gemma":[0.9795901,0.0007285092,0.0003319147,0.0006921389,0.0008471518,0.00001684021,0.00001528519,0.00004393531,0.01773411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1898734,"threshold_uncertainty_score":0.4776662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06407782425752495,"score_gpt":0.3316305130257619,"score_spread":0.267552688768237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}