{"id":"W4368361225","doi":"10.3324/haematol.2022.281580","title":"Germline loss of function &lt;i&gt;BRCA1&lt;/i&gt; and &lt;i&gt;BRCA2&lt;/i&gt; mutations and risk of &lt;i&gt;de novo&lt;/i&gt; hematopoietic malignancies","year":2023,"lang":"en","type":"letter","venue":"Haematologica","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Leukemia & Lymphoma Society of Canada; University of British Columbia","funders":"National Heart, Lung, and Blood Institute","keywords":"Germline; Germline mutation; Mutation; Genetics; Biology; Cancer research; Internal medicine; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006276458,0.0003788363,0.0006111999,0.0004902869,0.001321203,0.0009898739,0.0006170498,0.01242061,0.01142196],"category_scores_gemma":[0.003999566,0.0003487577,0.0004684701,0.0004167407,0.0008225729,0.0008156843,0.000270982,0.006191687,0.007258093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001691058,"about_ca_system_score_gemma":0.001009027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008045292,"about_ca_topic_score_gemma":0.009514942,"domain_scores_codex":[0.9995793,0.0001449353,0.00003169857,0.00006326279,0.000104172,0.00007666086],"domain_scores_gemma":[0.9982244,0.0009206436,0.0001165425,0.00009750372,0.0002892438,0.0003515824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.0003657839,0.0001023265,0.009508613,0.00004399532,0.00003588301,0.0219474,0.00008301873,0.0001859059,0.0007820398,0.002937941,0.948927,0.01508005],"study_design_scores_gemma":[0.000479562,0.0003463718,0.02318511,0.0005292249,0.0001368557,0.07894551,0.0005339823,0.002792243,0.001732166,0.02119217,0.8700189,0.0001078084],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.007414412,0.003260023,0.0002346084,0.9379171,0.01702241,0.00002306059,0.0006566375,0.00009118039,0.03338061],"genre_scores_gemma":[0.154037,0.006282728,0.0008780179,0.6738161,0.06638845,0.00009425872,0.0008013413,0.0001122505,0.09758974],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01242061,"threshold_uncertainty_score":0.03821021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01410661095178931,"score_gpt":0.244994479452877,"score_spread":0.2308878685010877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}