{"id":"W4368361225","doi":"10.3324/haematol.2022.281580","title":"Germline loss of function &lt;i&gt;BRCA1&lt;/i&gt; and &lt;i&gt;BRCA2&lt;/i&gt; mutations and risk of &lt;i&gt;de novo&lt;/i&gt; hematopoietic malignancies","year":2023,"lang":"en","type":"letter","venue":"Haematologica","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Leukemia & Lymphoma Society of Canada; University of British Columbia","funders":"National Heart, Lung, and Blood Institute","keywords":"Germline; Germline mutation; Mutation; Genetics; Biology; Cancer research; Internal medicine; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","research_integrity"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.001467931,0.001908373,0.00283807,0.0009462829,0.0007806795,0.0001977262,0.0013377,0.003537104,0.0004258295],"category_scores_gemma":[0.001307308,0.001863858,0.0009610584,0.001253825,0.00279587,0.00007703927,0.001134929,0.001252253,0.0001474482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003073309,"about_ca_system_score_gemma":0.001070566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001737341,"about_ca_topic_score_gemma":0.0005131664,"domain_scores_codex":[0.9900246,0.000959843,0.002807084,0.00290359,0.001403242,0.001901688],"domain_scores_gemma":[0.9922149,0.0008632173,0.002543794,0.002602847,0.001323257,0.0004520318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000428752,0.0004411071,0.0008861116,0.002842653,0.002047093,0.000717937,0.0008366935,0.0005783859,0.5692126,0.004367358,0.4166723,0.0009690264],"study_design_scores_gemma":[0.003783969,0.001667002,0.008337149,0.001119057,0.002964978,0.002920489,0.0001402119,0.0004399114,0.05316364,0.005639402,0.9165692,0.003255011],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8991991,0.0565974,0.005828357,0.02196889,0.002744172,0.003470803,0.004833381,0.0005432488,0.004814602],"genre_scores_gemma":[0.9306992,0.02655993,0.007993562,0.01067728,0.002838433,0.001505248,0.006332116,0.0007924689,0.01260173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5160489,"threshold_uncertainty_score":0.9999179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01410661095178931,"score_gpt":0.244994479452877,"score_spread":0.2308878685010877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}